Immunohistochemical Study of HER2/neu Expression in Colorectal Cancer and its Relation to other Clinicopathological Criteria and Prognostic Factors
Journal Title: International Journal of Cancer Management - Year 2017, Vol 10, Issue 5
Abstract
Background: Human epidermal growth factor receptor 2 (HER2) overexpression and amplification have been studied as a therapeutic and prognostic target in a number of tumors although conflicting data exist about the incidence and clinical consequence of HER2/neu status in the patients with colorectal cancer. The aim of the present study was to evaluate the immunohistochemical expression of HER2/neu and its relationship with clinicopathological parameters and prognostic factors. Methods: This study involved 50 specimens of malignant colorectal cancer lesions and HER-2/neu expression was evaluated by the Hercep-Test Kit. Results: Out of 50 cases, most of them (76%) were HER2/neu negative and in 12 (24%) cases, HER2/neu positive immunostaining were detected. 24% (n = 12), 36% (n = 18), 30% (n = 15), and 10% (n = 5) were scored as 3+, 2+, 1+, and 0 respectively. No significant association was noted between HER-2/neu expression and patients’ age, tumor size, gender, location, grade and stage (P > 0.05). Conclusions: The immunohistochemical evaluation of HER2/neu overexpression for potential targeted anti-HER2 therapy may not be valuable for the patients with colorectal cancer and also studies with larger sample sizes using standardized tests are needed to understand the exact biologic role of HER-2/neu in this type of tumor.
Investigation of Stigma Phenomenon in Cancer: A Grounded Theory Study
Background Adjustment to cancer as a stressful event is affected by bio-psycho-social factors. Objectives This study aimed to investigate stigma phenomenon, the process of formati...
Comparison of Three Clinical Models for Estimating the Risk of Endometrial Cancer in Post-Menopausal Women with Abnormal Vaginal Bleeding
Background: Given the prevalence of abnormal post-menopausal bleeding and the importance of its early examination for ensuring the timely diagnosis of any malignancies, the present study was conducted to investigate uter...
Antioxidant Supplements and Breast Cancer: A Systematic Review and Meta-Analysis
Context: Breast cancer is the second most common type of cancer worldwide and the most frequent one among women. Some studies suggest a favorable role of antioxidants on breast cancer, but this is still controversial. O...
Frequency of Chemotherapy Induced Anemia in Breast Cancer Patients
Background: Breast cancer is the second mostcommonmalignancy in women, worldwide. Several etiologic factors may cause anemia in a patient with breast cancer. Anemia is a prevalent complication in patients with breast can...
Triple Therapy with Doxorubicin, Imatinib and Tamoxifen in Recurrence Desmoids Tumor Associated with Pregnancy: Case Report and Literature Review
Introduction: Desmoid tumors, also known as aggressive fibromatosis, grow slowly but are locally aggressive. The therapy strategy consists of surgery, and radiation. Systemic therapy with non-steroidal anti-inflammatory...