Immunohistochemical study of Her2/neu marker status in urothelial tumors of bladder
Journal Title: MedPulse -International Medical Journal - Year 2017, Vol 4, Issue 2
Abstract
Background: Her2/neu is a marker of established clinical significance in the context of Her2/neu targeted therapy for breast carcinomas and gastric carcinomas. The present study was done to analyze the expression of Her2/neu in urothelial tumors of bladder in correlation with parameters like invasion, histological type and grade. Materials and methods: The retrospective study included 50 histologically diagnosed cases of urothelial tumors. The clinical and pathological findings were recorded. Immunohistochemical study was performed with Her2/neu marker on all cases and the findings were independently scored by two observers and consensus reached in case of any discrepancy. Results: The 50 cases of urothelial tumors included an age range of 40-90 years with a male: female ratio of 4:1. There were 40 cases (80%) of papillary tumors and 10 cases (20%) of non-papillary urothelial tumors. There was equal incidence of invasive urothelial carcinomas (50%) and non-invasive papillary urothelial carcinomas (50%). The Her2/neu positive expression (3+) was observed in 16 cases (32%) of the tumors. Equivocal results (2+) was identified in 11 cases (22%) and 23 cases (46%) were negative respectively. Conclusion: The incidence of Her2/neu positive expression (32%) in this study is comparable with other studies. The association with grade of tumors was found to be of some significance.
Authors and Affiliations
Elvin Jose, Shanthala P R, Ksheera Cariappa
Keywords
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