Immunohistochemical study of p53 expression as proliferative index in neoplasia of the uterine cervix
Journal Title: International Archives of Integrated Medicine - Year 2017, Vol 4, Issue 12
Abstract
Introduction: Cervical cancer is the third most common cancer in India. In women, it is the second most common after breast carcinoma. Human cancers arise from a protracted sequence of multiple genetic and epigenetic alterations which involve the growth regulatory genes like p53. Aim: This study aimed at correlation of immunopositivity of p53 with the histopathological type and grade of carcinoma cervix. Materials and Methods: A total of 100 cases of cervical biopsy/ hysterectomy specimens of carcinoma cervix received at the Department of Pathology, SMSMC Jaipur from January 2016 to September 2017 were examined for gross and microscopic features. Immunohistochemistry was used to study the p53 expression as proliferative index in cervical intraepithelial neoplasia, invasive squamous cell carcinoma as well as adenocarcinoma of the uterine cervix. Results: The demographic profile of SCC and CIN in this study was in concordance with that described by epidemiological studies in India with larger group of patients presenting with advanced stage tumors. Increased expression of p53 was found in increasing grades of CIN and SCC. The p53 positivity showed a statistically significant association with squamous cell carcinoma (SCC) histologic type (P = 0.005). Conclusion: The expression of p53 is greater in the malignant cervical neoplasms than pre-malignant cervical lesions, suggesting that p53 overexpression can be used as an early diagnostic tool and also as a prognostic indicator.
Authors and Affiliations
Monil Thakrar, Kusum Mathur
Keywords
Related Articles
- EP ID EP412859
- DOI -
- Views 95
- Downloads 0
A retrospective study of atrial septal defect
Background: An Atrial Septal defect is an abnormal hole of variable size in the atrial septum, which generally permits left to right shunting of blood at the atrial level. ASD is one of the most common congenital cardiac...
Effect of cigarette smoking on various biochemical parameters in patients attending OPD of RMMCH
Background: Smoking harms nearly every organ of the body and diminishes a person’s overall health. Millions and millions of peoples have health problems due to the habit of smoking. It is now a burden worldwide because s...
Histamine content in local consumers demanded fishes of Tuticorin
Histamine is a biogenic amine, which is developed in protein rich food as a result of histidine decomposition and this decomposition is caused by growth of certain types of bacteria. The biogenic amine of histamine conte...
Evaluation of modified shock index and mortality rate of patients at Emergency Department of tertiary care hospital in Tamil Nadu
Introduction: A number of systems or alerts are implemented in the ED to identify and bring resources to patients with traumatic injuries, ST-elevation myocardial infarctions, or acute strokes, but there is currently no...
Study to compare CT and MRI evaluation in cerebral venous thrombosis
Introduction: Cerebral venous thrombosis possible causal factors and clinical manifestations are many and varied; imaging plays a primary role in the diagnosis. Aim: The purpose of study was to compare CT and MRI findin...