Immunological and genotoxic effects of occupational exposure to α-cypermethrin pesticide
Journal Title: International Journal of Occupational Medicine and Environmental Health - Year 2017, Vol 30, Issue 4
Abstract
Objectives: The aim of this work has been to find out the occupational oxidative stress, immunological and genotoxic health hazards among α-cypermethrin (CYP) pesticide-exposed workers. Material and Methods: A cross-sectional study was performed including 200 workers divided into 3 groups according to the level of exposure: highly exposed group (50 workers), moderately exposed group (50 workers) and unexposed group (100 workers). All workers were subjected to detailed laboratory investigation for gene P53 mutations, immunological parameters as a cluster of differentiation into 3 percentage (CD3%), CD4% and CD8% in addition to peripheral blood total leukocytic and platelet counts that were measured. Spectrophotometer technique was used for detection of superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) and glutathione peroxidase (GPx). Air samples were collected with a High Volume Small Surface Sampler for measurement of α-cypermethrin level. Results: A highly exposed group to the α-cypermethrin had lower CD4/CD8 as compared to an unexposed group with statistically significant difference. As regards gene mutation, exons 5a and 6 were more frequent among the highly exposed group as compared to no mutation among moderately exposed and unexposed groups with significant difference. As regards antioxidants; SOD, CAT, GSH and GPx were higher among the unexposed group as compared to the highly and moderately exposed group with statistically significant difference. Significant negative correlation was found between working years and antioxidant parameters. Conclusions: Repeated exposure to α-CYP may lead to gene mutations, immunological disturbances and oxidative stress. Strict safety precautions are required not only for workers but also for public users. Int J Occup Med Environ Health 2017;30(4):603–615
Authors and Affiliations
El-Sayed El Okda, Mona Abdel-Aal Abdel-Hamid, Ahmed Mohamed Hamdy
Keywords
Related Articles
- EP ID EP181596
- DOI 10.13075/ijomeh.1896.00810
- Views 94
- Downloads 0
COMPARISON OF THE IN VITRO HEMOLYTIC EFFECTS PRODUCED BY ALKOXYACETIC ACIDS ON HUMAN AND RAT ERYTHROCYTES
[b]Objectives:[/b] The alkoxyacetic acids (AAAs) are urinary metabolites of alkoxyethanol solvents. It is well documented that these chemicals can cause acute hemolytic anemia in humans and laboratory animals. There are...
WORKPLACE EXPOSURES AND MALE INFERTILITY — A CASE-CONTROL STUDY
[b]Objectives: [/b]This study examined the association between male infertility and certain occupational exposures. [b]Material and Methods:[/b] A case-control study was carried out from January 2008 to February 2009; on...
Relationship between occupational stress and cardiovascular diseases risk factors in drivers
Objectives: Of all work stressors, occupational stress is the leading cause of many disorders among workers. Drivers are classified as a high risk group for work related stress. This study set out to determine the relati...
Screening survey of ocular, nasal, respiratory and skin symptoms in manicurists in Poland
Objectives: Manicurists are exposed to various chemicals in nail and skin care products and may develop ocular, nasal, respiratory or skin adverse reactions to them. To investigate the occurrence of ocular, nasal, respir...
Letter to the Editor (August 24, 2017) concerning the paper “Occupational exposure to radon for underground tourist routes in Poland: Doses to lung and the risk of developing lung cancer”
Refers to: Walczak K, Olszewski J, Politański P, Zmyślony M. Occupational exposure to radon for underground tourist routes in Poland: Doses to lung and the risk of developing lung cancer. Int J Occup Med Environ Health....