Immunological and Haematological Disturbances in Diabetes Mellitus: Modulatory Role of Diets Containing Vernonia amygdalina Leaves
Journal Title: European Journal of Medicinal Plants - Year 2015, Vol 6, Issue 3
Abstract
Aim: The aim of this study was to determine some makers of immunology and haematology in Streptozotocin -induced diabetic wistar rats consuming Vernonia amygdalina leaf diets in order to evaluate the involvement of the diets in the management of immunological and haematological complications among diabetics. Design and Methodology: Fifty albino wistar rats were divided into five groups with 10 rats in each group. Group 1 (normal control) was fed with control diet; Group 2 (diabetic control) was fed with control diet, Group 3 and 4 (diabetic treated with diets) were fed with Vernonia amygdalina leaf diet at 5% and 7.5%, respectively. Group 5 (diabetic treated with insulin) was fed with control diet and administered insulin. Feed and water were given ad- libitum for 28 days. Full blood count (FBC) was determined using automated haematology analyzer, KX2IN (non-cyanide hemoglobin analysis method. The CD4+ lymphocyte was estimated by flow cytometry using the cyflow automated cell counter (Parlec, Germany). Results: Results showed that diabetic rats consuming Vernonia amygdalina had significant (P < 0.5) increase in the RBC, haemoglobin, and lymphocyte counts relative to the diabetic control. Diabetic rats consuming Vernonia amygdalina had significant (P < 0.5) reduction in the level of WBC, platelets, neutrophil, and CD4+ cell count relative to the diabetic control. The results for Vernonia amygdalina diets were similar to insulin on the measured parameters and their levels were not significantly different (P >0.5) when compared to the normal control. Conclusion: We concluded that consumption of diets containing Vernonia amygdalina leaves might have positive effect on the immunological and haematological abnormalities associated with diabetes mellitus.
Authors and Affiliations
H. D. Akpan, I. F. Usoh
Keywords
Related Articles
- EP ID EP350246
- DOI 10.9734/EJMP/2015/14313
- Views 120
- Downloads 0
Ergot Alkaloids: A Review on Therapeutic Applications
Ergot of Rye is a plant disease caused by the fungus Claviceps purpurea which infects the grains of cereals and grasses but it is being used for ages for its medicinal properties. All the naturally obtained ergot alkaloi...
Nasal Snuff (Nigeria Local Smokeless Tobacco) Administration Raises Hepatic Enzyme Plasma Levels in Wistar Rats
Aims: Smokeless tobacco (ST) is commonly used in many countries and is considered as alternative to tobacco smoke (TS) in view of the increasing awareness of the hazardous effects of TS. This study investigated the effec...
Ethnomedicinal Survey on the Uses of Mistletoe in South-Western Nigeria
Survey on the ethnomedicinal uses of mistletoe in Southwestern Nigeria was carried out in various major market centers identified in the major capital towns of four different States in the Southwest Nigeria including Oyo...
Comparative Phytochemical Analyses and in-vitro Antioxidant Activity of Aqueous and Ethanol Extracts of Simarouba glauca (Paradise Tree)
Aims: The study was conducted to evaluate the phytochemical and antioxidant potentials of ethanol and aqueous leaf extracts of Simarouba glauca vis-à-vis standard antioxidants. Study Design: True experimental study. Plac...
Phytochemical and Biological Evaluation of MeOH Extract of Casuarina equisetifolia (Linn.) Leaves
Aims: The present study was aimed at investigating the phytoconstituents in order to correlate the folkloric claims with the bioactive compounds present in Casuarina equisetifolia. Also evaluate the antioxidant, antibact...