Immunological and Hematological Profiles of Human Immunodeficiency Virus Positive Patients on Antiretroviral Treatment Followed at Institute Pasteur of Ivory Coast
Journal Title: International Blood Research & Reviews - Year 2014, Vol 2, Issue 6
Abstract
Aims: The immune system and some of the organs of HIV positive patients may be subject of some disruptions caused by Anti-Retroviral Treatment (ART). This study has been initiated in order to assess the impact of ART on the immunological and hematological parameters of People Living with HIV (PLHIV) followed at Institute Pasteur of Ivory Coast (IPIC). Methodology: This cross-sectional study took place from August 2012 to August 2013 on 45 HIV-positive patients under first line ART, aged from 19 to 63 years of both genders with 30 women and 15 men. Three therapeutic treatments have been used during the study and are: the determination of CD4+ T-lymphocytes and the blood cells count have been determined before the beginning of ART. Profiles for CD4+ and blood cells count were studied every 15 days (D15), 6 months (M6) and 12 months (M12) after taking ART. Results: This study showed that CD4+ T-lymphocytes count was lower at first than 200 cells/mm3, has increased significantly from (P< 0.0001) to values greater than 350 cells/mm3 and restored the level of hemoglobin to its standard values after one year of antiretroviral treatment. With the exception of the TDF+FTC+EFV, all therapeutic combinations showed a neutropenia and a macrocytosis. These anomalies could be related to the presence of lamivudine (3TC) in the therapeutic combinations. Conclusion: This study showed that the ART restore the immune system, but could be a cause of anemia in the long term. Consequently, their use by HIV positives patients should be accompanied by some anti-anaemic treatment.
Authors and Affiliations
F. A. Yapo, A. F. J. Trébissou, C. C. A. Yapo-Crezoit, J. A. Djaman
Keywords
Related Articles
- EP ID EP242611
- DOI 10.9734/IBRR/2014/11109
- Views 129
- Downloads 0
Haematological Changes Associated With Hepatitis E Virus Seropositivity among Human and Animal Subjects in Plateau State, Nigeria
Aim: To investigate the haematological manifestations of Hepatitis E Virus (HEV) seropositivity. Study Design: Cross sectional study. We included 592 subjects in the study; (426 humans and 166 animals). Humans were cate...
Assessment of CD4 Count and Some Haematological Parameters of HIV Positive Patients Co-infected with Hepatitis B Virus in Osun State, Nigeria
Background: Increased morbidity and mortality rates have been reported among patients co-infected with Human Immunodeficiency Virus (HIV) and Hepatitis B Virus (HBV). Aims: To determine the prevalence of HBV infection am...
A Case Report of Pregnant Woman with Aplastic Anemia: Diagnosis and Management through Subsequent Pregnancy
Introduction: Aplastic anemia is characterized by decreased bone marrow function with inadequate production of erythrocytes, granulocytes, and platelets. Marrow failure may be caused by absence of or defects in hematopoi...
Enzymatic and Non-enzymatic Biomarkers Levels in Pregnancy Trimesters in Ilesa South Western Nigeria
Aims: The aim of this study was to see the effect of pregnancy on some selected enzymatic and non-enzymatic biomarkers based on trimesters. Study Design: One-factor, one control - three test group quasi - experimental d...
Serum Leptin and Adiponectin Levels in de Novo Acute Myeloid Leukemia Patients: Correlation with Clinical Characteristics
Aim of the Study: Acute myeloid leukemia (AML) is a heterogeneous clonal stem cell malignancy characterized by proliferation of immature hematopoietic cells. Adipokines in particular leptin and adiponectin are highly act...