Immunomodulating Efficacy Of Different Adjuvants In Formulation Of Foot And Mouth Disease Vaccine Relative To Its Immunogenicity
Journal Title: Journal of Applied Veterinary Sciences - Year 2020, Vol 5, Issue 3
Abstract
The ideal adjuvant is one that able to aid in early stimulation of the humeral immune response, and to promote the production of high antibody titers that would persist for long duration as well as stimulate the cellular immune response. This immunological study was conducted to reveal the aluminum hydroxide gel effect with the use of oil adjuvants on the immune response of polyvalent foot and mouth disease (FMD) vaccine in sheep. Twenty five sheep, were divided to five group (five animals/group) where the 1st group was vaccinated with polyvalent FMD ISA 206 oil vaccine, 2nd group was vaccinated with polyvalent FMD ISA 206 + aluminum hydroxide gel vaccine, 3rd group was vaccinated with polyvalent ISA 201 oil vaccine, 4th group was vaccinated with polyvalent ISA 201 + aluminum hydroxide gel vaccine, 5th group was kept as a negative control (non-vaccinated). Blood and Serum samples were collected from vaccinated animals for monitoring the cellular and humeral immune responses. The results showed that sheep groups immunized with the vaccine prepared with ISA 201with aluminum hydroxide gel is considered the best cellular and humeral immunity post vaccinal response then ISA 201 followed by ISA 206 with aluminum hydroxide gel and the last one is the vaccine prepared with ISA 206 alone.It can be concluded that, ISA oils with aluminum hydroxide gel induce the best cellular and humeral immunity.
Authors and Affiliations
El-Sayed, E. I. ; Mossad, W. G. ;Hassanin A. I. and Shabana, W.
Keywords
Related Articles
- EP ID EP684203
- DOI 10.21608/JAVS.2020.98318
- Views 211
- Downloads 0
An overview of Animal and Human Brucellosis in Nigeria
Brucellosis is a bacterial disease in humans and animals caused by a group of organisms in the genus Brucella. It is highly contagious and one of the most important zoonosis in the world. The disease remains endemic in N...
Evaluation Of Using Different Adjuvants Used For Preparation Of Staphylococcus Aureus Mastitis Vaccine On The Immune Response
Staphylococcus aureus (S. aureus) was the most prevalent bacteria recorded from clinical and subclinical mastitis. The main objective of the present work is to prepare and evaluate the effectiveness of locally prepared i...
Comparative Anticoccidial Potential of Maxiban 160 and Herb-All COCC-X against Eimeria Species Infestation on Intestinal Lesion and Oocyte Shedding in Broilers
Coccidiosis is the most serious protozoan disease of poultry industry worldwide. Infected birds shed the infective oocysts in high numbers in the droppings which enables the persistence of the disease in the flock. Tradi...
Morphology of the Spleen in the Camel's Fetus (Camelus dromedarius): Gross Anatomy, Histology and Scanning Electron Microscopic Studies
The spleen is essential for immunological responses to infections that are carried in the blood. The study aimed to investigate the gross anatomy, topography, histology and scanning electron microscopy of the spleen in t...
Roles Of Tumor Necrosis Factor In Animal Tissues : Review Article
Inflammation is a particular portion of tissue response to harmful inflammogens roles of it with interleukins, and systemic effects of TNF. This response including different types of inflammatory cells like (neutrophils,...