Immunomodulatory Potential Of Rutin And Quercetin In Swiss Mice Exposed To Gamma Radiation
Journal Title: International Journal of Biomedical and Advance Research - Year 2017, Vol 8, Issue 8
Abstract
Radioprotective mechanisms of Rutin (RUT) and Quercetin (QRT) against gamma radiation was studied by investigating recovery of endogenous spleen colony-forming units, haematological alterations in peripheral blood in Swiss albino mice. Radiation induced haematological alterations in peripheral blood was studied; mice were treated with RUT (10mg/kg.b.wt.) and QRT (20mg/kg.b.wt.) once daily for five consecutive days and exposed to 7.5 Gy of gamma radiation after the last administration. RUT and QRT treatment before exposure to 7.5 Gy of gamma radiation resulted in a significant (p<0.01) increase in cellular components of blood at various post-treatment time points when compared with the respective irradiated groups. Irradiation of mice reduced the spleen colony forming units in the spleen and the number of spleen nodules was inversely related with the increase in radiation dose. The potent antioxidant nature of RUT and QRT mitigate the oxidative stress induced by gamma radiation and thus protect the mice from hemopoietic damage.
Authors and Affiliations
Shrikant L. Patil, Shilpa Patil, Nageshwar B. Rao, H M Somashekarappa
Keywords
Related Articles
- EP ID EP384099
- DOI 10.7439/ijbar.v8i8.4297
- Views 56
- Downloads 0
Comparison of clinical performance of I-Gel with LMA-Proseal in elective surgeries under general anesthesia
Aim: To compare insertion characteristics of two different supraglottic devices [I-gel and LMA-Proseal] and to observe any associated complications. Materials and Methods: This prospective, randomized study was conducted...
Study of serum uric acid levels in acute ST elevation myocardial infarction patients and its correlation with Killips classification of heart failure
Aims: To estimate serum uric acid levels in acute ST elevation myocardial infarction patients and its correlation with killips classification of heart failure. Methods : 100 Patients with Acute ST elevation myocardial i...
Synthesis And Biological Evaluation Of Benzimidazole Derivatives As An Antitubercular And Antimicrobial Agents
Heterocyclic Compounds especially with Benzimidazole, Thiophene & Piperazine moieties were synthesized and investigated for their biological activities.The Increasing global tuberculosis burden due to the curse of HI...
Aggressive Angiomyxoa of Vulva: Wide local excision case report
Aims and Background: Aggressive angiomyxoma is rare tumor of pelvic and perineal organs, occurring usually in women of reproductive age, and carrying a high tendency to local infiltration and relapse. It is non-malignant...
Tuberculosis of wrist joint with rice body formation: A case report
Tuberculosis of the wrist and hand is a rare infectious disease, Because of the rarity of these cases, early diagnosis is often difficult. We report a case of 55-year-old male agriculture worker came to our OPD due to a...