Immunomostimulant phytoconstituents from Mangifera indica L. bark oil
Journal Title: The Journal of Phytopharmacology - Year 2014, Vol 3, Issue 2
Abstract
The present study was undertaken to isolate oil from Mangifera indica bark, Identification of various phytoconstituents and screening of immunostimulant activity in experimental animals. Methods: Immunostimulant activity was evaluated in rats as well as in mice by determining neutrophil adhesion to nylon threads and phagocytic index. Levamisole at a dose of 50 mg/kg, b.w was used as standard drug. Acute toxicity studies were carried out and the test drug doses were selected. Mangifera indica bark oil in the dose of 150 & 300 mg/kg b.w, p.o, were used. Results: Results indicate a significant increase in percent neutrophil adhesion (P<0.01) for test and standard groups compared to control group and haemagglutination antibody (HA) titer (P<0.01) and phagocytic index (P<0.001) values are also significantly increased in test groups. Conclusion: The results obtained in the present study indicate that Mangifera indica Linn bark oil possesses potent immunomodulatory activity and have therapeutic efficacy for the prevention of autoimmune and infectious diseases.
Authors and Affiliations
Chetan Savant, Anand Rao Kulkarni, Basheerahmed Abdulaziz Mannasaheb, Rahul Gajare
Keywords
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