Immunotherapy for B-Cell Neoplasms using T Cells expressing Chimeric Antigen Receptors From antigen choice to clinical implementation
Journal Title: Sultan Qaboos University Medical Journal - Year 2012, Vol 12, Issue 3
Abstract
Immunotherapy with T cells expressing chimeric antigen receptors (CAR) is being evaluated as a potential treatment for B-cell neoplasms. In recent clinical trials it has shown promising results. As the number of potential candidate antigens expands, the choice of suitable target antigens becomes more challenging to design studies and to assess optimal efcacy of CAR. Careful evaluation of candidate target antigens is required to ensure that T cells expressing CAR will preferentially kill malignant cells with a minimal toxicity against normal tissues. B cells express specifc surface antigens that can theoretically act as targets for CAR design. Although many of these antigens can stimulate effective cellular immune responses in vivo, their implementation in clinical settings remains a challenge. Only targeted B-cell antigens CD19 and CD20 have been tested in clinical trials. Tis article reviews exploitable B cell surface antigens for CAR design and examines obstacles that could interfere with the identifcation of potentially useful cellular targets.
Authors and Affiliations
Mohamed-Rachid Boulassel| Division of Hematology, Royal Victoria Hospital, McGill University Health Centre, Montreal, Quebec, Canada, Department of Haematology, College of Medicine & Health Sciences, Sultan Qaboos University Hospital, Muscat, Oman, Ahmed Galal| Division of Hematology, Department of Medicine, University of Saskatchewan, Saskatoon Saskatchewan, Canada
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