Impact of bariatric surgery on non-alcoholic fatty liver disease

Journal Title: Polish Journal of Surgery - Year 2017, Vol 89, Issue 2

Abstract

Introduction; p to 300 million people have the body mass index (BMI) greater than 30 kg/m2. Obesity is the cause of many serious diseases, such as type 2 diabetes, hypertension, and non-alcoholic fatty liver disease (NAFLD). Bariatric surgery is the only effective method of achieving weight loss in patients with morbid obesity. Objectives: The aim of the study was to assess the impact of bariatric surgery on non-alcoholic fatty liver disease in patients operated on due to morbid obesity. Material and Methods: We included 20 patients who were qualified for bariatric procedures based on BMI > 40 kg/ m2 or BMI > 35kg/m2 with the presence of comorbidities. The average body weight in the group was 143.85kg, with an average BMI of 49.16kg/m2. Before the procedure, we evaluated the severity of non-alcoholic fatty liver disease in each patient using the Sheriff-Saadeh ultrasound scale. We also evaluated the levels of liver enzymes. Follow-up evaluation was performed twelve months after surgery. Results: Twelve months after surgery, the average weight was 102.34 kg. The mean %WL was 33.01%, %EWL was 58.8%, and %EBMIL was 61.37%. All patients showed remission of fatty liver disease. Liver damage, evaluated with ultrasound imaging, decreased from an average of 1.85 on the Sheriff-Saadeh scale, before surgery, to 0.15 twelve months after surgery (p < 0.001). As regards liver enzymes, the level of alanine aminotransferase decreased from 64.5 (U/l) to 27.95 (U/l) (p < 0.001), and the level of aspartate aminotransferase decreased from 54.4 (U/l) to 27.2 (U/l). Conclusions: Bariatric procedures not only lead to a significant and lasting weight loss, but they also contribute to the reduction of fatty liver disease and improve liver function.<br/><br/>

Authors and Affiliations

Piotr Major, Michał Pędziwiatr, Mateusz Rubinkiewicz, Maciej Stanek, Anna Głuszewska, Magdalena Pisarska, Andrzej Budzyński

Keywords

Related Articles

Roux-en-Y gastric bypass as a cure of iatrogenic – steroid induced diabetes

Background Steroid induced diabetes (SIDM) is a frequently found clinical condition since steroid-based therapies continue to be widely used in hospital and ambulatory care. Recommended optimal treatment of SIDM include...

Dostęp nadobojczykowy do żyły podobojczykowej – przypadek zapomnianej metody dającej imponujące rezultaty

Cel pracy: Założenie cewnika tymczasowego lub tunelowanego do żyły szyjnej wewnętrznej do hemodializy uważane jest za „złoty standard”. Z drugiej strony, dostęp nadobojczykowy do żyły podobojczykowej został opisany już w...

Inhibicja zależnego od PERK proadaptacyjnego szlaku sygnałowego, jako nowe podejście w leczeniu chorób nowotworowych

Retikulum endoplazmatyczne (Endoplasmic Reticulum; ER) jest organellum komórkowym, które odgrywa istotną rolę w rozwoju komórek oraz utrzymaniu homeostazy. Ostatnie dane wskazują, iż liczne choroby człowieka, włączając r...

Download PDF file
  • EP ID EP187484
  • DOI 10.5604/01.3001.0009.6003
  • Views 105
  • Downloads 0

How To Cite

Piotr Major, Michał Pędziwiatr, Mateusz Rubinkiewicz, Maciej Stanek, Anna Głuszewska, Magdalena Pisarska, Andrzej Budzyński (2017). Impact of bariatric surgery on non-alcoholic fatty liver disease. Polish Journal of Surgery, 89(2), 1-4. https://europub.co.uk/articles/-A-187484