Impact of Calcium-Vitamin D Supplements on the Dissolution Pattern of Ranitidine Hydrochloride Tablets: An in vitro Dissolution Study using UV Spectroscopy
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2016, Vol 5, Issue 5
Abstract
The objective of this study was to evaluate the impact of Calcium-Vitamin D supplement formulations on the dissolution pattern of different Ranitidine Hydrochloride tablet formulations. This was an in-vitro dissolution study using USP apparatus II and UV spectroscopy. Three different brands of Ranitidine hydrochloride i.e. Brand A, Brand B and the innovator brand ‘Zantac®’ were chosen. Besides CS1, CS2 and CS3 were the three Calcium-Vitamin D tablet brands used to carry out the experiments. In our study, all the brands of Ranitidine HCl tablets satisfied the USP requirements by showing dissolution of more than 80% within 60 minutes when tested alone. The dissolution patterns were 98%, 96% and 94% respectively for Brand A, Brand B and ‘Zantac®’. However, their dissolution rates were significantly reduced when they were tested with the Calcium-Vitamin D tablets. With the Brands CS1, CS2 and CS3, the percent drug releases were 50%, 46% and 75% for Brand A, 48%, 49% and 73% for Brand B and 49%, 48% and 72% for ‘Zantac®’. These results may be due to the common ion effects and/or the altered dissolution medium environment. Therefore, this study suggests separate intake of Ranitidine and Calcium supplements to ensure a better therapeutic efficacy. Keywords: Dissolution, Ranitidine Hydrochloride, Calcium, Vitamin D, UV spectroscopy.
Authors and Affiliations
Tirtha Nandi
Keywords
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