Abstract

Aim of the work: this study aimed to explore the association between diabetes duration on both the extent and severity of coronary atheroma burden using coronary computed tomography angiography (CCTA) in type 2 diabetic patients. Patients and methods: we analyzed 105 symptomatic type 2 diabetic patients without known CAD who underwent CCTA from August 2016 to June 2017. Patients were categorized into two groups according to the duration of diabetes: < 10 years, and ≥ 10 years. Stenosis by CCTA was scored as none (0%), non-obstructive (1–49%), or obstructive (≥50%) for each coronary artery segment. For these patients, we compared the prevalence, extent, and severity of CAD, including coronary artery calcium score (CACS), atheroma burden obstructive score (ABOS), segment involvement score (SIS), segment stenosis score (SSS) and syntax score. Results: patients with longer duration of type 2 diabetes possessed higher rates of obstructive CAD. Patients with longer duration of diabetes also manifested greater degree of CACS, ABOS, SIS, SSS and syntax score (P < 0.001 for all). Conclusion: in symptomatic type 2 diabetic patients, longer diabetes duration was associated with a higher prevalence, extent, and severity of CAD so, increased risk of developing atherosclerotic cardiovascular disease including major events as myocardial infarction or even sudden cardiac death.

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