Impact of Iron and Vitamin B12 Anaemia at Glycosylated Hemoglobin Level: A Case Control Study
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 1
Abstract
Introduction: Diabetes Mellitus (DM) refers to a group of common metabolic disorder. It is a complex, chronic illness requiring continuous medical care with multifactorial risk reduction strategies beyond glycemic control. HbA1c which was primarily used as a test of glycemic control has now been added as a diagnostic test. One condition that effect erythrocyte turnover is anemia. Iron and Vitamin B12 deficiency inhibit erythropoiesis and increase the mean survival duration of erythrocyte, leading to increase HbA1c. Methods: The study was conducted in tertiary care hospital, Jaipur. The study involved 60patients out of which 30 were of Iron deficiency anemia and remaining 30 had Vitamin B 12 deficiency anemia. Permission was taken from the ethical committee before starting the study. A well informed written consent was taken prior to the study and the results of the same were compared with 30 non anemic, non diabetic controls using ANOVA and T test analysis. Results: Out of 30 participants in each group, 36.67% were male and 63.335% were female in iron deficiency group, 53.33% were male and 46.67% were female in vitamin B12 deficiency group, 60% were male and 40% were female in control group.In Iron deficiency anemia 10 out of 30 participants (33.33%) had Hba1c in the range of impaired glucose homeostasis(5.6 -6.5)2 and in Vitamin B12 deficiency anemia 12 out of 30 participants (40%) had Hba1c in the range of impaired glucose homeostasis. Interestingly 2 patients from irondeficiency anemia had Hba1c in diabetic range (more then 6.5). Our study reported significant negative trend when Hemoglobin was compared with HbA1c in patients with iron deficiency anemia, that is, patients with lower Hemoglobin had higher HbA1c. Conclusion: Anemia and Diabetes are a common problem in Indian scenario and use of HbA1c to diagnose prediabetes and diabetes in iron-deficient populations may lead to a spuriously exaggerated prevalence of prediabetes.
Authors and Affiliations
Dr VD Maheshwari, Dr. Shekhar Capoor, Dr. Surbhi Chaturvedi, Dr. Ankit Manglunia, Dr. Ankush Singla
Keywords
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