Impact of Iron Deficiency Anemia on Hba1c Levels among Non - Diabetic Patients
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 3
Abstract
Introduction: Glycated hemoglobin,HbA1c is the “gold standard” formonitoring glycemic control and is been used as a predictor of diabetic complications. Being one of the common forms of malnutrition, it attributes to 50% of all forms of anemia, globally. It’s been found previously that reduced iron stores have a link with increased HbA1c, leading to false-high values of HbA1c in non-diabetic individuals. Even though iron deficiency anemia is the most common nutritional deficiency, the clinical evidence suggestive of the influence of Iron Deficiency Anemia on HbA1c is inconsistent. Objectives: To evaluate the association between Iron Deficiency Anemiaand HbA1c values. Methodology: Observational Cross–sectional study was conducted on 50patients attending OPD / admitted to Government Rajaji Hospital & Madurai Medical College during the study period from February 2017 to July 2017. By Simple Random Sampling, patients with anemia, normal fasting and postprandial plasma glucose levels, normal liver function tests, normal blood urea and serum creatinine levels were recruited for this study. Results: Twenty Five participants were in the iron deficiency anemia groupand 25 in the control (normal) group. The mean age of cases was 40.3 ± 10.7 years and mean age of controls was 38.4 ± 12.9 years. There were 27 (54 %) females and 23 (46 %) males. Mean Hb among cases was 8.48 ± 1.5 (5.4 to 10.9 gm/dL) and that among controls was 14.2 ±0.8 (12.3 -15.5 gm/dL). The total mean FBS and PPBS were 88.0 ± 7.8 and 124.0 ± 8.5 respectively. The mean HbA1c was 6.5 ± 0.6. The mean HbA1c for cases with Iron Deficiency Anemia was more than that for healthy controls (7.1 ± 0.3 and 6.0 ± 0.3 respectively) (p-value <0.0001). Conclusion: Iron deficiency was associated with higher proportions ofHbA1c, which could cause problems in the diagnostic and therapeutic interpretation of the HbA1c concentrations. Hence, the iron status must be considered during the interpretation of the HbA1c.
Authors and Affiliations
S Kadhirvel, A Tamilvanan
Keywords
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- EP ID EP555865
- DOI 10.9790/0853-1803095661.
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