Impact of laparoscopic ovarian drilling on anti-mullerian hormone levels in women with clomiphene resistant polycystic ovary syndrome
Journal Title: Indian Journal of Obstetrics and Gynecology Research - Year 2017, Vol 4, Issue 3
Abstract
Introduction: Patients with PCOS not only have raised androgen levels which leads to anovulation but may also have high AMH levels. When ovulation induction fails, androgen levels are reduced by laparoscopic ovarian drilling (LOD) thereby effecting ovulation and thus improving fertility. Studies have suggested that LOD also reduces AMH levels and the degree of its fall may forecast the success of LOD. Materials and Method: The study objective was to evaluate baseline AMH levels and its change post LOD in patients with clomiphene resistant infertility, and correlate with spontaneous rates of ovulation and pregnancy. Results: AMH levels were found to be high in clomiphene resistant PCOS. LOD was found to be safe and effective in the management of these patients and it caused statistically significant drop in AMH levels effecting spontaneous ovulations and pregnancies. Though the degree of fall did not correlate statistically with the success of the procedure, the chances of pregnancy were found to better in patients whose pre-LOD AMH levels were higher. Conclusion: AMH levels could be a useful marker in PCOS related infertility with clomiphene resistance and LOD could be a safe and effective option for management of patients with high AMH levels and fall in AMH levels may emerge as a prognostic indicator. Randomized studies with adequate sample size would bring out the utility AMH as a prognostic marker in PCOS related infertility.
Authors and Affiliations
Monica Saraswat, Tony Jose, Meenakshi Rajput, Nilopher Siddique
Keywords
Related Articles
- EP ID EP314960
- DOI 10.18231/2394-2754.2017.0066
- Views 89
- Downloads 0
“Moments Of Life: made possible” by Hospice „SAMVEDANA‟
Introduction: Palliative care is an approach that improves the quality of life of patients and their families facing the problems associated with life-threatening illness, through prevention and relief of suffering by me...
Diagnostic hysterolaparoscopy in evaluation of female infertility in a Rural Medical College
Objective: To study the efficacy of combined diagnostic hystero-laparoscopy in evaluation of causes of female infertility. Methods: Ours was a retrospective study conducted in the Department of Obs & Gyn from January 201...
Knowledge, attitude, and practices of family planning methods among women of reproductive age attending OPD in tertiary care centre, Lucknow, Uttar Pradesh
Introduction India with 134 billion people is the second most populated country in the world while china is on the top with over 141 billion people Total fertility rate of India is 22 and the current total fertility rate...
Case report: A rare case of vaginal leiomyoma
Leiomyoma is the most common benign tumor of uterus and rarely it may be seen in other parts female reproductive system like the round ligament uterosacral ligament inguinal canal and vagina There are only few cases repo...
Retrospective Observational Study of Caesarean Section Cases in a Tertiary Care Hospital in Odisha
Objective: To study the incidence and indications of LSCS. Place and Duration: This study was carried out from January to July 2016 in Department of Obstetric and Gynaecology, KIMS, Bhubaneswar Methodology: In this retro...