Impact of malaria infection on renal and liver functions in patients living with HIV/AIDS on HAART in Douala, Cameroon
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2016, Vol 4, Issue 11
Abstract
Abstract: Malaria and HIV (Human immunodeficiency virus) infection are known overlap in Sub-Saharan Africa countries. Thus, it is likely in this context that the burden inflicted by these both diseases is more important. This study was designed to determine the prevalence of malaria and its impact on renal and hepatic profiles in people living with HIV (PLWHIV) on HAART (Highly active antiretroviral therapy) and living in Douala. Between August 2015 and March 2016 a prospective and cross-sectional study was carried out at the District hospital of Deido in the town of Douala. Questionnaire form was used to document sociodemographic, clinic and biological data of participants. Blood samples were collected by venipuncture into tubes for biological analyses. These allowed to performed thick blood films for malaria diagnosis. Sera were obtained and used to measure transaminases and creatinine levels. A total of 723 patients were included in the study. The mean age of the population was 39.49 ± 11.17 years old. The malaria prevalence was 16.7% (95%CI = 14.2% - 19.6%). AST (aspartate aminotransferase) and ALT (alanine aminotransferase) were higher in malaria positive patients on average. In addition, the difference was statistically significant for ALT (p-value = 0.0403). In addition, creatinine levels were lower in malaria positive patients compared to their negative counterparts. Renal and liver functions were both further impaired in malaria positive patients especially ALT which is more specific of liver function. This study outlines the need for appraising the measurement of transaminases and creatinine especially in PLWHIV during their management. Keywords:HIV/AIDS, Malaria, Co-infection, transaminases, Creatinine, Douala
Authors and Affiliations
KamgainMawabo Lugarde, Assam AssamJean Paul, KojomLoick Pradel, KamgaFouamno Henri Lucien
Keywords
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