Impact of pre-operative 200 µg (P/R) per rectal misoprostol on blood loss during and after Cesarean delivery
Journal Title: International Archives of Integrated Medicine - Year 2016, Vol 3, Issue 6
Abstract
Background: Intra-partum and early postpartum blood loss are increased in conjunction with Cesarean delivery. Misoprostol is a potent uterotonic agent that has been extensively studied in the prevention and treatment of PPH after vaginal delivery, however, its use in conjunction with CD has not been investigated as much. Objective: To evaluate the effect of preoperative administration of rectal misoprostol on blood loss during and after elective Cesarean delivery. Materials and methods: A randomized controlled trial was conducted among 200 women scheduled for elective Cesarean delivery. The study group (n=100) received 200 µg of misoprostol. The control group (n=100) received placebo. The main outcome measures were intra-operative blood loss, postpartum blood loss at 24 hours, and difference between preoperative and postoperative hematocrit values. Results: The mean intra-operative and postpartum blood loss was lower in the study group than the control group: 374 ± 69.9 ml and 131 ± 31.8 ml versus 401 ± 79.9 and 145 ± 35.6 ml, respectively. The difference between the preoperative and postoperative hematocrit values was also significantly lower in the study group than the control group (4.3 ± 2.26 and 5.25 ± 2.61, p =0.006). Admissions to the neonatal intensive care unit and Apgar scores at 1 and 5 minutes were comparable between the two groups. Conclusion: Preoperative administration of 200 µg rectal misoprostol significantly reduced blood loss related to elective Cesarean delivery.
Authors and Affiliations
K. Aruna Kumari, E. Swathi, Sarada Saranu
Keywords
Related Articles
- EP ID EP428797
- DOI -
- Views 80
- Downloads 0
Wound healing rates in HIV patients - Correlation with cd4 and cd8 counts
Background: Human immunodeficiency virus (HIV) constitutes one of the most difficult challenges facing the healthcare profession today. A few studies showed the CD4 count to be a weak surrogate end point of clinical outc...
Papillon lefevre – A rare syndrome
Papillon lefevre syndrome (PLS) belongs to a heterogeneous group of skin diseases that are characterized by hyperkeratosis of palms and soles and presence of severe and early onset periodontitis. Genetic studies have sho...
Assessment of audiologic evaluation in patients with acquired hypothyroidism
Introduction: Hypothyroidism is a common endocrine disorder resulting from deficiency of thyroid hormone or, more rarely, from their impaired activity at tissue level. In its clinically overt form, hypothyroidism is a re...
Pulmonary Arterial Enlargement is Associated with Acute Chest Pain in Patients without Coronary Artery Disease
Background: Pulmonary hypertension (PH) is an uncommon cause for chest pain in patients without significant coronary artery disease (CAD). Therefore, we studied the association between chest pain, right ventricular dimen...
Laparoscopic cholecystectomy for biliary dyskinesia in patient with an extended spectrum of ejection fraction on hepatobiliary iminodiacetic acid scan
Background: Biliary dyskinesia is a condition where the gallbladder motility is seen as abnormal. Diagnostic imaging studies for biliary dyskinesia usually include a negative or inconclusive abdominal ultrasound or compu...