Impact of thrombus aspiration conjugative with Anisodamine for the Prevention of No-reflow phenomenon following primary Percutaneous coronary intervention
Journal Title: Preventive Medicine Research - Year 2013, Vol 2, Issue 1
Abstract
Objective:We sought to evaluate the combination therapy of thrombus aspiration plus anisodamine in prevention of No-reflow phenomenon during percutaneous coronary intervention. method: from October 2009 to June,143 consecutive patients with Stemi who received manual thrombus aspiration were involved in a double Center prospectively analysis.The patients were treated with anisodamine (1000 fig/kg)plus Tirofiban (pg/kg) (Group A,n = Tirofiban and pg/kg alone (group B,n = respectively.The drugs were selectively injected into the infarct-related artery (IRA),Through the occlusion to the distal segment via the Thrombus ASPI Theration catheter advanced MTO the IRA.Primary endpoints were postprocedural corrected thrombolysis in myocardial frame count (infarction).The proportion of complete c>70%)St-segment resolution (STR) myocardial blush Grade 2~3 (MBG) post PCI.Secondary endpoints included peak value of creatine kinase-MBTIMI flow grade;6-month outcome including left ventricular ejection fraction (LVEF),b16> as acardiac death target vascular revascularization,Re-infarction and their combination as major adverse cardiac events (MACE).result:Baseline characteristicswere not different between two groups.Compared to group B,Group A had①A lower corrected TIMI coronary flame count (_p<0.b20>,②ahigher proportionof completest-Segment Resolution (_P<0). *PetroChinaHuabei Oilfield Company Science and technology project(no:2012-hb-g09-4 1North China Petroleum Administration General Hospital Heart II(Hebei Renqiu,062552 2North China Petroleum Administration General Hospital Maternity and Gynecology3Hebei Medical University Second Hospital Department of Cardiology Communications ③a better myocardial blush 2-3grade ratio (_p = 0.),and④A lower peak creatine kinase-mb (_p0.()), There is no differences in TIMI 3 flow grade between the two groups (P []B20>0.No differences were foundin Cardiac Death, tvr,rinfarction,mace,between The two groups during 6-month follow-up only a improvement trend in group eight(P0.05).Nevertheless, LVEF at 6 month is higher in group eight(P(0.01). Conclusion: preventively intracoronary Administration of Anisodamine 1000 ug via thrombus aspiration catheter can improve myocardial reperfusion for acute stemi with initial timi 2 treated with primary PCI.
Authors and Affiliations
Zhao yujun, Maxiaoxiao, Dongqiuh, Fuxianghua, Liushaoyun
Keywords
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