Impact of Thyroid Dysfunction on Renal Glomerular Filtration Rate, Sodium and Potassium among Sudanese Patients Attending Ribat Teaching Hospital
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2016, Vol 4, Issue 3
Abstract
Abstract: Thyroid hormones (TH) are essential for an adequate growth and development of the kidney. Thyroid dysfunction causes remarkable changes in glomerular, tubular functions, electrolyte and water homeostasis. The aim of this study was to assess alteration in glomerular filtration rate (GFR) and electrolyte (Na+ and K+) in patients with thyroid dysfunction. Case control study conducted in Khartoum State at Alribat Hospital, during May to August 2015. A hundred and fiveheparinized plasma samples divided into study group (70 samples) and control groups(35 samples).Thyroid dysfunction patients as study group subdivided into 35 samples from hyperthyroidism patient and 35samples from hypothyroidism, matched in age (18-60 years) and sex with apparently healthy individuals as control group, and GFR was calculated using Cockcroft-Gault equation, plasma creatinine level which determine enzymaticlly by using (BS MINDRAY380), and Na+ and K+ were estimated by Easylyte in mmol/l instrument while thyroid hormone ( T3, T4 and TSH) were estimated by enzyme linked immunosorbent assay (ELISA). GFR in ml/min (mean±SD) in hypo, hyperthyroidism and normal respectively (56.08 ± 15.2, 81.14±17.5, and 105.6±9.02)ml/min. Na+mmol/l (140.5± 4.75, 138.4±7.53, and 139.3.+2.3)mmol/l. While K+mmol/l (4.09 0.49, 4.9 0.57and 4.04±0.3) mmol/l. In summary, Thyroid dysfunction and GFR are interrelated significant reduction of GFR in both hypo and hyperthyroidism when comparing with control group and there is insignificant relation between Thyroid dysfunction and electrolyte (Na+, K+) when comparing with control group. Keywords: Glomerular Filtration Rate, Electrolyte, Thyroid hormone, Sudanese.
Authors and Affiliations
Riham Hashim, Siddig B. Mohamed, Rimaz A. Gurashi, Gad Allah Modawe, AbdElkarim A. Abdrabo
Keywords
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