Impact of Voglibose on of Metabolic Control Indicators in Patients with Diabetes Mellitus Type 1
Journal Title: Міжнародний ендокринологічний журнал - Year 2015, Vol 1, Issue 65
Abstract
New therapeutic options to control diabetes mellitus (DM) emerged with the discovery of alpha-glucosidase inhibitors which slow the absorption of carbohydrates in the small intestine. The objective of the study — to investigate the effect of voglibose administration on parameters of glycemic control, lipid metabolism and tolerability in patients with DM type 1. Materials and Methods. Criteria for inclusion in the study: DM type 1, age from 26 to 48 years, the level of glycated hemoglobin (HbA1c) from 8 to 9 %. 19 patients were examined (7 men and 12 women, mean age 37.2 ± ± 3.9 years, DM duration 8.5 ± 1.4 years. Results. During the follow-up period (12 weeks), the level of HbA1c significantly decreased from 9.4 ± 0.6 % to 7.8 ± 0.4 % (p < 0.05). On the background of additional administration of voglibose, we observed a significant reduction in fasting glucose level from 10.37 ± 0.36 mmol/l to 7.39 ± 0.28 mmol/l (p < 0.01) and postprandial — from 12.29 ± 1.42 mmol/l to 8.46 ± 0.64 mmol/l (p < 0.01). At that, we have noted a significant reduction of total cholesterol (from 5.83 ± ± 0.11 mmol/l to 5.38 ± 0.08 mmol/l, p < 0.05), triglycerides (from 1.82 ± 0.03 mmol/l to 1.46 ± 0.03 mmol/l, p < 0.05) and low-density lipoprotein cholesterol (from 3.41 ± 0.05 mmol/l to 3.37 ± ± 0.04 mmol/l, p < 0.05). There were no significant changes in high-density lipoprotein cholesterol parameters. In two surveyed persons, we have detected adverse effects (bloating), which did not require discontinuation of therapy. Conclusion. Additional administration of voglibose at a dose of 0.9 mg/day on a background of insulin therapy helps to improve glycemic control and lipid metabolism, to reduce the daily dose of exogenous insulin and hypoglycemic reactions incidence in patients with DM type 1.
Authors and Affiliations
V. I. Pankiv
Keywords
Related Articles
- EP ID EP223171
- DOI -
- Views 53
- Downloads 0
Giant pituitary adenomas: prevalence, features of diagnosis clinical course
Based on the review of the literature, it is established that in the diagnostic complex with giant pituitary adenomas, in addition to clinical examination, it is necessary to use a full range of neuroimaging methods wit...
Brain Lesions in Patients with Type 2 Diabetes Mellitus
The objective of research — to establish the causes and patterns of structural and functional changes in the brain of patients with type 2 diabetes with ischemic stroke in order to improve the diagnosis, evaluation of th...
New Basal Insulin Toujeo Solostar: Increased Therapeutic Potential for the Control of Dysglycaemia in Diabetes Mellitus
This review examines the new formulation of insulin glargine (recombinant) in the form of injections 300 U/ml (Gla‑300, Toujeo®). Gla‑300 is a next generation basal insulin with a novel formulation of insulin glargin del...
Primary hyperaldosteronism. Mechanisms and consequences of pathological influence on an organism (review of literature)
The work is based on the analysis of world literature data on primary hyperaldosteronism. The data on mechanisms of pathological influences of excessive autonomous aldosterone secretion on the body systems are given. The...
Lymph node dissection in differentiated thyroid cancer: review of modern tendencies
Recently, there has been a significant increase in the incidence of thyroid cancer (TC), both due to the adverse environmental effects and the rapid development of imaging methods. This led to the search for adapted and...