Impact of Voglibose on of Metabolic Control Indicators in Patients with Diabetes Mellitus Type 1
Journal Title: Міжнародний ендокринологічний журнал - Year 2015, Vol 1, Issue 65
Abstract
New therapeutic options to control diabetes mellitus (DM) emerged with the discovery of alpha-glucosidase inhibitors which slow the absorption of carbohydrates in the small intestine. The objective of the study — to investigate the effect of voglibose administration on parameters of glycemic control, lipid metabolism and tolerability in patients with DM type 1. Materials and Methods. Criteria for inclusion in the study: DM type 1, age from 26 to 48 years, the level of glycated hemoglobin (HbA1c) from 8 to 9 %. 19 patients were examined (7 men and 12 women, mean age 37.2 ± ± 3.9 years, DM duration 8.5 ± 1.4 years. Results. During the follow-up period (12 weeks), the level of HbA1c significantly decreased from 9.4 ± 0.6 % to 7.8 ± 0.4 % (p < 0.05). On the background of additional administration of voglibose, we observed a significant reduction in fasting glucose level from 10.37 ± 0.36 mmol/l to 7.39 ± 0.28 mmol/l (p < 0.01) and postprandial — from 12.29 ± 1.42 mmol/l to 8.46 ± 0.64 mmol/l (p < 0.01). At that, we have noted a significant reduction of total cholesterol (from 5.83 ± ± 0.11 mmol/l to 5.38 ± 0.08 mmol/l, p < 0.05), triglycerides (from 1.82 ± 0.03 mmol/l to 1.46 ± 0.03 mmol/l, p < 0.05) and low-density lipoprotein cholesterol (from 3.41 ± 0.05 mmol/l to 3.37 ± ± 0.04 mmol/l, p < 0.05). There were no significant changes in high-density lipoprotein cholesterol parameters. In two surveyed persons, we have detected adverse effects (bloating), which did not require discontinuation of therapy. Conclusion. Additional administration of voglibose at a dose of 0.9 mg/day on a background of insulin therapy helps to improve glycemic control and lipid metabolism, to reduce the daily dose of exogenous insulin and hypoglycemic reactions incidence in patients with DM type 1.
Authors and Affiliations
V. I. Pankiv
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