IMPAIRED ANDROGEN METABOLISM: A MAJOR CAUSE OF UNDER VIRILIZATION IN MALE CHILDREN
Journal Title: World Journal of Pharmaceutical and Medical Research - Year 2017, Vol 3, Issue 1
Abstract
Background: Testosterone is the primary male sex hormone, and anabolic steroid. It plays a key role in the development of the male reproductive organ. Design and Setting: A retrospective hospital based study was conducted at King Khaled University Hospital (KKUH), Riyadh, Saudi Arabia during the period January 1989 and June 2016. Material and Method: During the period under review all patients with abnormal androgen metabolism were retrospectively reviewed. Medical records were reviewed for age, clinical characteristic, family history and results of all laboratory and radiological investigations. Result: During the period under review; 36 patients were evaluated for undervirilization. Variable causes were noted with androgen insensitivity (44.4%) and 5 alpha reductase (27.8%) were among the commonest. Gonadotrophin deficiency was found in (11.1%). While testosterone biosynthesis impairment in six (16.7%) patients. Conclusion: A diversity of causes can lead to androgen impairment of which androgen insensitivity and 5 alpha reductase deficiency were among the commonest. Appropriate investigations and, hence, diagnosis are needed for proper management.
Authors and Affiliations
Nasir A. M. Al Jurayyan
Keywords
Related Articles
- EP ID EP650976
- DOI -
- Views 211
- Downloads 0
RECENT APPLICATION OF SOLVENT FREE GREEN SYNTHESIS OF SCHIFF’S BASES AND IT’S DERIVATIVES: A REVIEW
The Chemistry has wide scope for Carbon-Nitrogen bond forming reactions and upgrade from traditional towards modern synthetic and mutidisciplinary methods. The preferred interesting topic in chemistry that may benefit fr...
ASSOCIATION BETWEEN APOLIPOPROTEIN A5-1131T>C (RS662799) GENE POLYMORPHISM AND LIPID PROFILE IN ISCHEMIC HEART DISEASES
Background: the most common type of Ischemic Heart Diseases, includes :stable and un stable angina and myocardial infarction, a chronic condition that narrows arteries by building fat-filled bulges in the arterial walls....
UNDERSTANDING OF AAM AND ROLE OF AYURVEDIC ANTIOXIDANTS ON IT
In our body, there is a continuous process known as metabolism. During such metabolic changes free radicals are produced by the normal activity of body and are harmful for our body especially as in the long term. They ar...
PREGNANCY FOLLOWING KIDNEY TRANSPLANT: CASE REPORT AND LITERATURE REVIEW
Pregnancies in women with chronic kidney failure are considered as high-risk pregnancies because there are some possible complications that may occur during pregnancy and may affect the mother, the foetus, or both of the...
IN VITRO EFFICACY OF TEMPERATURE AND PRESERVATIVES ON FAST FOOD BACILLI, AND THEIR ANTIBIOTIC SUSCEPTIBILITY PROFILE
Background and Objective: Species within the Bacillus genus are ubiquitous, and cause food infections and intoxications. Bacillus species are however rarely assayed for in convenience foods. Furthermore, consumer health...