IMPAIRED ANDROGEN METABOLISM: A MAJOR CAUSE OF UNDER VIRILIZATION IN MALE CHILDREN
Journal Title: World Journal of Pharmaceutical and Medical Research - Year 2017, Vol 3, Issue 1
Abstract
Background: Testosterone is the primary male sex hormone, and anabolic steroid. It plays a key role in the development of the male reproductive organ. Design and Setting: A retrospective hospital based study was conducted at King Khaled University Hospital (KKUH), Riyadh, Saudi Arabia during the period January 1989 and June 2016. Material and Method: During the period under review all patients with abnormal androgen metabolism were retrospectively reviewed. Medical records were reviewed for age, clinical characteristic, family history and results of all laboratory and radiological investigations. Result: During the period under review; 36 patients were evaluated for undervirilization. Variable causes were noted with androgen insensitivity (44.4%) and 5 alpha reductase (27.8%) were among the commonest. Gonadotrophin deficiency was found in (11.1%). While testosterone biosynthesis impairment in six (16.7%) patients. Conclusion: A diversity of causes can lead to androgen impairment of which androgen insensitivity and 5 alpha reductase deficiency were among the commonest. Appropriate investigations and, hence, diagnosis are needed for proper management.
Authors and Affiliations
Nasir A. M. Al Jurayyan
Keywords
Related Articles
- EP ID EP650976
- DOI -
- Views 232
- Downloads 0
PAIN MANAGEMENT IN PAEDIATRIC PRACTICE: THE VIEWS OF PAEDIATRIC HEALTH CARE PROVIDER ON THE USE OF ANALGESICS
Background: Pain remains a common event in paediatric practice. Whether brought on by disease, injury or a necessary procedure, alleviation of pain in children remains a topical issue, an area of continuing research and...
HEALTH RELATED BEHAVIOUR AND LIFE STYLE SURVEY OF THE 1ST YEAR MBBS STUDENTS OF NISHTAR MEDICAL COLLEGE
Background: A regular habit is essential for the preservation of health because healthy body has healthy mind. Objective: To determine the health related behaviour and lifestyle of the 1st Year MBBS students of Nishtar M...
CANCER OF THE HYPOPHARYNX: CLINICAL BEHAVIOUR, PROGNOSTIC FACTORS AND POSTOPERATIVE QUALITY OF LIFE
In spite of advancements in surgical intervention and chemoradiotherapy (CRT) for head and neck cancer, the prognosis for advanced-stage squamous cell carcinoma of the hypopharynx (HPSSC) remains poor. The relatively poo...
APPLIED ASPECT OF AMAVATA CHIKITSA SUTRA
Context: In ayurveda, most of the diseases are named taking into consideration either the vitiated dosha, dushya, avayava, marga, lakshan and karma. In the same way amavata has been named, taking into account two predomi...
THE EFFECT OF USING MANAGEMENT OF KNOWLEDGE ON INNOVATION AND ORGANIZATIONAL FUNCTION IN HYGIENE CENTER OF BOUSHEHR-2016
Introduction: By paying attention to the importance and management of knowledge in innovation and organizational function and their staff in this study, our aim was answering this question: Was management of knowledge ef...