Implications of vitamin D insufficiency/deficiency in autoimmune diseases: A review
Journal Title: Revista Uningá - Year 2021, Vol 58, Issue 1
Abstract
Vitamin D is a fat-soluble steroid hormone with a wide range of biological effects that go beyond the regulation of calcium metabolism and bone health, reaching a preponderant role in maintaining systemic homeostasis, related to cell growth, differentiation and apoptosis, regulation of immune systems, cardiovascular and muscle and insulin metabolism; participating in the direct or indirect modulation of about 3% of the human genome. Considering the serious complications arising from vitamin D deficiency for health and life quality, a descriptive study was proposed in this work, which relates the insufficiency / deficiency of this vitamin to some autoimmune diseases such as systemic lupus erythematosus, diabetes mellitus, multiple sclerosis, rheumatoid arthritis and inflammatory bowel disease (Crohn's disease). This study was developed from 58 articles, among which include review articles, original articles from clinical and experimental research, published between 2008 to 2020, obtained from the research in the database Pubmed®, Google Scholar and Scientific Electronic Library Online (SCIELO). Based on studies related to autoimmune diseases, it can be concluded that vitamin D exhibits crucial immunomodulatory function, ensuring an efficient protection system. Studies that deal with vitamin D supplementation, both for the prevention and treatment of existing autoimmune diseases are necessary and of great value for understanding these implications.
Authors and Affiliations
Angela Maria Pereira Alves, Izabela Aparecida Marques Cesilio, Eder Paulo Belato Alves, Marli Aparecida Defani, Larissa Carla Lauer Schneider.
Keywords
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- EP ID EP712940
- DOI doi.org/10.46311/2318-0579.58.eUJ3437
- Views 70
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