Importance of bcl2 Protein Expression in Histological Negative Margins after Excision of Oral Squamous Cell Carcinoma
Journal Title: World Journal of Medical Research - Year 2017, Vol 6, Issue 1
Abstract
Background B cell lymphoma-2 (bcl-2) is an intercellular membrane associated protein that functions as anti apoptotic protein via mitochondria mediated intrinsic pathway of caspase activation. We evaluated expression of bcl2 protein in patients with oral cancer and in adjacent normal tissue. Patients and methods Bcl-2 protein expression was evaluated in patients with oral cancer undergoing surgical resection using immunohistochemistry (IHC) in the tumour tissue and the adjacent normal tissue. Results Bcl2 protein expression was not seen in any tumour tissue however, in the normal margin 61 cases showed bcl2 expression. This expression was cytoplasmic in all the cases. Conclusions This expression in margins correlated with lymphatic spread of the disease and suggest poor prognosis in this subset of the patients. The mRNA expression, polymorphism, mutations, SNP’s were not looked at in the present study and hence, the exact significance of the results is not clear.
Authors and Affiliations
Manoj Pandey, Devendra K Ravi, Mohan Kumar, Mridula Shukla
Keywords
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- EP ID EP536895
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Importance of bcl2 Protein Expression in Histological Negative Margins after Excision of Oral Squamous Cell Carcinoma
Background B cell lymphoma-2 (bcl-2) is an intercellular membrane associated protein that functions as anti apoptotic protein via mitochondria mediated intrinsic pathway of caspase activation. We evaluated expression of...