IMPROVEMENT BY THE AQUEOUS EXTRACT OF THE LEAVES OF DESMODIUM VELUTINUM WILL DC (FABACEAE) OF BIOLOGICAL PARAMETERS ALTERED BY ETHANOL 30 % IN RATS
Journal Title: World Journal of Pharmaceutical Research - Year 2018, Vol 7, Issue 10
Abstract
Most epidemiological data show that regular alcohol consumption is related to an increase the occurrence of cardiovascular diseases, dysfunction of noble organs and changes in biochemical and hematological parameters. The objective of this work is to evaluate the effects of the aqueous extract of the leaves of D. velutinum on the consequences of the subchronic excessive consumption of ethanol 30 % in the wistar rat. Alterations in biological parameters (rat weight, noble organ masses, ALT, ASAT, white blood cells, red blood cells, hemoglobin and platelets) were induced by ethanol overload 30 % daily for eight (8) weeks. The detection of flavonoïds in this extract was made by Thin Layer Chromatography (TLC). At the doses of 250 and 500 mg/kg the aqueous extract improves the biological parameters. This extract contains flavonoïds. Other activities to deepen the effects of the aqueous extract of the leaves of D. velutinum on the alterations of the biological parameters induced by the ethanol 30% deserve to be realized.
Authors and Affiliations
Etou Ossibi A. W.
Keywords
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