IMPROVEMENT OF FAST DISINTEGRATING TABLETS USING RANITIDINE HCL
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2013, Vol 1, Issue 7
Abstract
The present study was designed towards the design and development of fast disintegrating tablets by direct compression technology using Ranitidine HCl as a model drug. Fast disintegrating tablet of Ranitidine HCl was formulated using two Superdisintegrants in different concentrations i.e. 30 mg and 35 mg. Kollidon CL and Sodium Starch Glycolate are used as Superdisintegrants. All the batches were prepared by direct compression method using the Single punch tablet compression machine using 13 mm diameter. Disintegration time and drug release were taken as the basis to optimize the immediate release tablet. Prepared tablets were evaluated for thickness, hardness, friability, uniformity of weight, disintegration time and dissolution study. Tablets containing 30 mg Kollidon CL showed the faster disintegration time (25-30 Secs) and percent of drug release (90% in 15mins) as compared to other superdisintegrating agent.
Authors and Affiliations
Rishikesh*| Department of Pharmacy, University of Asia Pacific, Dhanmondi, Dhaka-1209, Bangladesh, Mst Rikta Banu| Department of Pharmacy, University of Rajshahi, Rajshahi-6205, Bangladesh, Md. Zakaria Faruki| Department of Pharmacy, University of Asia Pacific, Dhanmondi, Dhaka-1209, Bangladesh, Drishti Rani Ghosh| Department of Pharmacy, University of Asia Pacific, Dhanmondi, Dhaka-1209, Bangladesh, Mohiuddin Ahmed Bhuiyan| Department of Pharmacy, University of Asia Pacific, Dhanmondi, Dhaka-1209, Bangladesh, Irin Dewan| Department of Pharmacy, University of Asia Pacific, Dhanmondi, Dhaka-1209, Bangladesh
Keywords
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