Improving the diagnosis and treatment of hepatobiliary pathology in adolescents with obesity
Journal Title: Здоров`я дитини - Year 2018, Vol 13, Issue 0
Abstract
Background. The prevalence of obesity among adolescents is increasing, and hepatobiliary pathology is often associated with it. Timely diagnosis and treatment of liver pathology, including non-alcoholic fatty liver disease, and biliary pathology prevent the development of severe complications of obesity. The purpose of the study is to evaluate the structural and functional state of the hepatobiliary system using dynamic echography and to optimize treatment of hepatobiliary disorders among adolescents with obesity. Materials and methods. The study involved 27 patients with obesity aged 12–17 years. A clinical, laboratory and instrumental examination were conducted, which included dynamic echography using Chophytol. The therapeutic possibilities of Chophytol were studied. Results. The study shown that increased appetite, abdominal pain and nausea were leading complains among adolescents with obesity. Signs of moderate atherogenic dyslipidemia were found during the biochemical analysis. Signs of steatohepatosis were observed in 88.8 % of patients according to echography data. Hypokinesis of the gallbladder was detected in 92.6 % of cases. In the majority of patients, there was a hypotonic-hypokinetic type of functional disorders of the biliary tract, an increase in the size of the gallbladder. Comprehensive treatment with Chophytol for 1 month has resulted in positive effects: general well-being has improved, dyspepsia and pain syndrome have decreased; in 52.0 % of patients, the size of the liver has decreased, in 32.0 % — the normalization of echogenicity of the liver parenchyma has occurred; in 28.0 % of adolescents, the contractile function of the gallbladder has improved. Conclusions. In the majority of adolescents with obesity, signs of steatohepatosis and hypotonic-hypokinetic type of functional disorders of the biliary tract are determined. Dynamic echography using Chophytol allows evaluating the function of both the gallbladder and the sphincter apparatus. The application of Chophytol in the comprehensive therapy among obese adolescents with signs of steatohepatosis and with hypokinetic type of functional disorders of the biliary tract is well-founded.
Authors and Affiliations
L. K. Parkhomenko, L. A. Strashok, M. Yu. Isakova, A. V. Yeshchenko, M. A. Khomenko, O. S. Pavlova, T. M. Kvaratskheliya
Keywords
Related Articles
- EP ID EP292296
- DOI 10.22141/2224-0551.13.0.2018.131180
- Views 90
- Downloads 0
Prediction of long-term effects of juvenile idiopathic arthritis
Background. Juvenile idiopathic arthritis (JIA) is characterized by chronic inflammation of the joints with progressive course and a strong tendency to development of early disability. Long-term follow up of a patients w...
Modern aspects of the choice of mucoactive cough therapy in pediatric practice
The article presents the main approaches to the administration of mucoactive cough therapy in pediatric practice. Some of medicines most commonly used in children such as ambroxol and carbocysteine and their combination...
Magnets — Aggressive and Dangerous Foreign Bodies of the Digestive Tract in Children
Foreign bodies of the digestive tract in children are common. Each year children swallow more 100,000 foreign bodies. In recent years the list of species added. Particular attention should be paid to such aggressive fore...
Mechanism of Action of Activated Oxygen-Containing Metabolites in the Respiratory Tract. Anti-inflammatory Action (Part 3)
The review provides the general idea about the mechanisms of anti-inflammatory action of activated oxygen-containing metabolites. The participation of activated oxygen-containing metabolites in the regulation of apoptosi...
Echocardiography and ultrasound dopplerography assessment of central and peripheral hemodynamics in children with septic shock
Background. The severe course of sepsis is usually associated with the development of septic shock and multiple organ failure. For effective treatment, it is recommended to perform instrumental monitoring of preload, con...