IMPROVING THE OUTPUT OF SIGNALING PATHWAY IMPACT ANALYSIS
Journal Title: Revista Romana de Statistica - Year 2013, Vol 61, Issue 3
Abstract
Recently biologists want to find out the significant gene sets instead of individual gene. Many packages in different software mostly in R language were developed to find out the gene sets which are significantly regulated. Among them some packages are able to discover up and down regulation as well. Signaling pathway impact analysis (SPIA) is one of them. In this study an approach is mentioned which can be improved the output of SPIA. I proposed that using moderated t values gives more significant results instead of using logFC (log fold change) from Limma’s output in order to calculate probability of perturbation in SPIA
Authors and Affiliations
Mohammad Ohid ULLAH
Keywords
Related Articles
- EP ID EP120376
- DOI -
- Views 142
- Downloads 0
Integrating R and Java for Enhancing Interactivity of Algorithmic Data Analysis Software Solutions
Conceiving software solutions for statistical processing and algorithmic data analysis involves handling diverse data, fetched from various sources and in different formats, and presenting the results in a suggestive, ta...
Aspects Regarding the Evolution of the Production of Goods and Services in Romania
The structure of the industrial productions reveals that necessary goods for population’s consumption and economic activity have had a structure that passes through a process of stabilization, determined by the general s...
Impactul absorbţiei fondurilor europene în asigurarea macrostabilităţii
Iniţiativa de la Viena are ca scop asigurarea ca procesul de dezintermediere să fie unul controlat şi de succes, pentru a minimiza riscurile sistemice ale Europei emergente. Întărirea cooperării între ţările de origine ş...
Analiza corelaţiei dintre PIB, consumul privat şi public prin regresie multiplă
Analiza corelaţiilor dintre indicatori, prin regresia multiplă, completează informaţiile şi concluziile extrase prin aplicarea unor modele de tip regresie simplă. Elementele suplimentare obţinute prin utilizarea regresie...
The Utility of the Credibility Theory
In this paper, we give the mathematical theory of the credibility model incorporating risk volumes. In the simple model of Section 1, we assumed that the risk volume was the same for all years. Often, in particular in re...