In silico adme and biological activity assessment of natural phytoconstituents for anti-alzheimer potential
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH - Year 2015, Vol 7, Issue 2
Abstract
Phytoconstituents such as, Wedalolactone Demethylwedalolactone, Valeranone, Jatamansin, Gamma gurjunene, beta-caryophyllene alpha humulin, Oleic acid, Palmitic acid, Linoleic acid, Gallic acid, Ellagic acid, Withafirin A, Withanolide D, Bacoside A, Bacoside B, Asiaticoside, Trans Asarone, Beta/cis asarone Glycyrrhizin, Glycyrrhizic acid and Licoisoflavanone were included in the present in silico analysis to evaluate their Anti-Alzheimer’s potential. The adsorbtion, distribution, metabolism, excretion (ADME) properties of these phytochemicals were assessed through Lipinski rule of Five. The Bioactivity properties and Phytoconstituents-likeness of the selective phytoconstituents were calculated using Molinspiration and Molsoft tools and their toxic properties were determined by employing the Osiris server. Interestingly, after application of Lipinski’s rule of five, our results revealed that all these selected phytoconstituents have fully satisfied the Lipinski’s rule of five and thus shall be recommended as safe phytoconstituents for effective treatment of AD though in vitro and in vivo study required in preclinical and clinical phases.
Authors and Affiliations
Lalit R. Samant, 2Anuya Rege and 1, 2Abhay Chowdhary
Keywords
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