IN SILICO ADME AND TOXICITY STUDY OF SOME SELECTED ANTINEOPLASTIC DRUGS
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2016, Vol 8, Issue 1
Abstract
Cancer is a serious health problem that recognized as a group of diseases involving uncontrolled cell growth. Majority of cancer chemotherapeutic agents have serious toxicity profile. Due to this use of these agents are limited. Therefore, it is essential requirement for developing new chemotherapeutic agents to devoid toxicity. In this research work, we study the pharmacokinetic, toxicity and bioactivity profile of few selected chemotherapeutic agents by In silico method. These research investigations provide the lead for the development of new cancer chemotherapeutic agents with lesser toxicity and more effectiveness.
Authors and Affiliations
Chandra Shekhar Sharma, Shashank Shekher Mishra, Hamendra Pratap Singh, Neeraj Kumar
DEVELOPMENT AND EVALUATION OF SUSTAINED RELEASE FLOATING MICROSPHERES CONTAINING ROPINIROLE HCL
Current investigation was to develop gastro retentive floating microsphere for Ropinirole. These microspheres of Ropinirole were prepared by ionic gelation method with an aim of increasing the gastric residence time and...
IN SILICO PHARMACOKINETIC, BIOACTIVITY AND TOXICITY STUDY OF SOME SELECTED ANTI-ASTHMATIC AGENTS
Asthma is a disease affecting the airways that carry air to and from lungs. Exposure to various irritants and substances that trigger allergies (allergens) can trigger signs and symptoms of asthma. The prevalence of asth...
HPTLC METHOD DEVELOPMENT AND VALIDATION OF ZOLPIDEM TARTRATE IN BULK AND MARKETED FORMULATION
High performance thin layer chromatography (HPTLC) offers many advantages over HPLC. It reduces the cost of analysis as compare to HPLC. The mobile phase consumption per sample is extremely low in HPTLC, hence reducing t...
GARCINIA LANCEIFOLIA ROXB; AN ENDEMIC MEDICINAL PLANT OF ASSAM RELIEVES PAIN AND DELAYS NOCICEPTIVE RESPONSE: AN ASSAY FOR ITS ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY
The stem bark of Garcinia lanceifolia, a lesser known species of the genus Garcinia, was extracted with methanol after pretreatment with petroleum ether. The resultant extract was evaluated for its analgesic and anti-inf...
MICROWAVE ASSISTED SYNTHESIS AND CHARACTERIZATION OF SCHIFF BASE OF 2-AMINO BENZIMIDAZOLE
New Schiff base (2-[(1H-benzimidazol-2-ylimino) methyl]-4,6- diiodophenol) was synthesized by the condensation of aryl/hetero aromatic aldehyde (3,5diiodosalicylaldehyde) with 2- amino benzimidazole under conventional an...