In silico Identification of Inhibitors from Salacia reticulate Plant against Diabetic Target Protein
Journal Title: International Journal of Current Microbiology and Applied Sciences (IJCMAS) - Year 2017, Vol 6, Issue 1
Abstract
Salacia species for its antdiabetic property especially of root, stem and leaf extract. Plant produces several phytochemicals responsible for antidiabetic activity. Four proteins were selected based on literature survey and retrieved from protein data bank. The 18 chemicals were converted into 3 D structure and docked with diabetic protein. Benzeneacetonitrile, .Alpha.-(.Beta.-D-Glucopyranosyloxy)-,(R)- is a chemical expressed in salacia which showed good antidiabetic property among 18 other chemicals. Benzeneacetonitrile, .Alpha.-(.Beta.-D-Glucopyranosyloxy)-, (R)- inhibit the diabetic causing proteins and regulate the glucose level in animal system. This study will helpful in future for developing a novel drug to treat diabetes by using advance in silico tools
Authors and Affiliations
D. Ramakrishna, A. T. Shashank, S. Kiran, K. M. Kumar, G. A. Ravishankar
Keywords
Related Articles
- EP ID EP567714
- DOI 10.20546/ijcmas.2018.701.050
- Views 74
- Downloads 0
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