IN SILICO LIGAND-BASED 2D PHARMACOPHORE GENERATION FOR H+/K+ ATPASE INHIBITORS
Journal Title: Universal Journal of Pharmaceutical Research - Year 2017, Vol 2, Issue 4
Abstract
At the beginning of the 20th century, Peptic Ulcer became the most prevalent disease as non-steroidal anti-inflammatory drugs (NSAIDs) proved ineffective. Researches proved proton pump inhibitors as most successful drugs for the treatment of peptic ulcer. Hence, a ligand based pharmacophore was generated on Ligand Scout based on fifteen selected H+/K+ ATPase inhibitors. A pharmacophore model with three Hydrogen bond acceptors, one Hydrogen bond donor and one Hydrophobic Domain was developed. The distance between these features was estimated on Visual Molecular Dynamics (VMD) software. The range between HBA-HBD was found to be 1.89-2.96A. The range between HBD-HP was 4.00-5.46A and range between HP-HBA was 1.89-2.96A. This research study will thus help in designing new and effective drugs for the treatment of peptic ulcer disease.
Authors and Affiliations
Sidra Ajmal, Shanza Khan
THE EFFECT OF TRAFFIC FACTORS AND TECHNOLOGY FACTORS ON CHRONOLOGICAL DELAY OF EMERGENCY (115) ON THE BESIDES OF INJURED PEOPLE IN BOYER AHMAD CITY IN 2017
The aim of this study is to investigate traffic factors and technology factors on chronological delay of emergency (115) on the besides of injured people in Boyer Ahmad city in 2017. The research method of this investiga...
RISK FACTORS OF PERIODONTAL DISEASES AMONG YEMENI YOUNG DENTAL PATIENTS
Periodontal diseasesare chronic infectious diseases that lead to the inflammation of specialized tissues that surround and support the teeth. Many risk factors and risk indicators, associated with increased risk of perio...
Editorial Message.
It gives me immense pleasure to express my deepest congratulations to all staff and members of Universal Journal of Pharmaceutical Research (UJPR) for their progressive and steady success in scientific publication pathwa...
DEVELOPMENT AND EVALUATION OF IN SITU GELLING GASTRORETENTIVE FORMULATIONS OF MELOXICAM
The aim of this study was to develop a novel gastro retentive oral floating in situ gelling system for controlled release of Meloxicam. Meloxicam is a NSAID that inhibits cyclooxygenase (COX) synthesis and has analgesic...
A REVIEW ON GOLD NANOPRTICLES SYNTHESIS AND CHARACTERIZATION
Gold nano particles (GNP) have exceptional biocompatibility and possess unique structural, electronic, magnetic, optical, catalytic and molecular recognition properties. Hence GNPs are very attractive for many biological...