In-Silico Methodologies for Cancer Multidrug Optimization
Journal Title: INTERNATIONAL JOURNAL OF COMPUTERS & TECHNOLOGY - Year 2018, Vol 17, Issue 2
Abstract
Drug combinations is considered as an effective strategy designed to control complex diseases like cancer. Combinations of drugs can effectively decrease side effects and enhance adaptive resistance. Therefore, increasing the likelihood of defeating complex diseases in a synergistic way. This is due to overcoming factors such as off-target activities, network robustness, bypass mechanisms, cross-talk across compensatory escape pathways and the mutational heterogeneity which results in alterations within multiple molecular pathways. The plurality of effective drug combinations used in clinic were found out through experience. The molecular mechanisms underlying these drug combinations are often not clear, which makes it not easy to suggest new drug combinations. Computational approaches are proposed to reduce the search space for defining the most promising combinations and prioritizing their experimental evaluation. In this paper, we review methods, techniques and hypotheses developed for in silico methodologies for drug combination discovery in cancer, and discuss the limitations and challenges of these methods.
Authors and Affiliations
Doaa Mohamed Hasan, Ahmed Sharaf Eldin, Ayman Elsayed Khedr, Hanan Fahmy
Keywords
Related Articles
- EP ID EP649751
- DOI 10.24297/ijct.v17i2.7168
- Views 85
- Downloads 0
A multifaceted semantic web service description of the pervasive information system
The technique of adapting the web service allows the user to establish reusable, interoperable, flexible and context-aware applications. In fact, the pervasive system specification is provided by the context-aware applic...
An Extended Recommendation System using Data Mining Implemented for Smart Phones
In this paper we introduce a recommendation system that attempts to solve some of the issues of classical recommendation systems: the need for huge amounts of data to be able to extract meaningful patterns, or for dire...
Performance Analysis of Malicious nodes on Multi hop Cellular Networks
The existence of malicious nodes in multi hop cellular networks, which operate without a central administration infrastructure, can result in performance degradation or even disruption of the network operation. In this p...
Assessing the Critical Factors for E-Learning Systems Using Fuzzy TOPSIS and Fuzzy Logic
Assessing the success of Information Systems (ISs) has been identified as one of the most critical issues in IS field. Offering more services and the ease of access is considered as a significant factor for today’s aca...
Fast Effective Deterministic Primality Test Using CUDA/GPGPU
There are great interests in understanding the manner by which the prime numbers are distributed throughout the integers. Prime numbers are being used in secret codes for more than 60 years now. Computer security authori...