IN SILICO PHARMACOKINETIC, BIOACTIVITY AND TOXICITY EVALUATION OF SOME SELECTED ANTI-ULCER AGENTS
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2017, Vol 9, Issue 2
Abstract
Peptic ulcer is a major health burden that recognized as a group of upper gastro-intestinal tract disorders. The aim of the therapy is to provide relieve from pain and prevent ulcer complications. Therefore, it is essential to evaluate the drug-likeness and toxicity profile of existing drugs for developing new potent anti-ulcer agents. In this research work, we study the pharmacokinetic, toxicity and bioactivity profile of few selected anti-ulcer agents by In silico method. These research investigations provide the lead for the development of new anti-ulcer agents with lesser toxicity and more effectiveness.
Authors and Affiliations
Neeraj Kumar, Shashank Shekhar Mishra, Chandra Shekhar Sharma, Hamendra Pratap Singh, Harshda Pandiya
Keywords
Related Articles
- EP ID EP617862
- DOI 10.25004/IJPSDR.2017.090205
- Views 103
- Downloads 0
USE OF ANTIHYPERTENSIVES IN PATIENTS HAVING ASSOCIATED RENAL PARENCHYMAL DISORDERS: CROSS SECTIONAL PRESCRIPTION PATTERN STUDY IN A TERTIARY CARE HOSPITAL
Hypertension is both a cause and a consequence of renal parenchymal disease. Once detected, formulation of an appropriate therapeutic strategy is imperative to not only control hypertension, but also to retard the progre...
UV-SPECTROPHOTOMETRIC DETERMINATION OF NATEGLINIDE IN BULK AND PHARMACEUTICAL DOSAGE FORM USING HYDROTROPIC SOLUBILIZATION TECHNIQUE
Nateglinide is practically insoluble in water, sparingly soluble in strong acid; soluble in strong bases. It is an anti-diabetic, effective in treatment of diabetes. Solubility of Nateglinide is increased by using 0.1M P...
IN SILICO VALIDATION OF ANTI-TUBERCULOSIS ACTIVITY IN ANDROGRAPHIS PANICULATA (BURM.F.) NEES
Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Although drugs are available for its treatment, administrations of those drugs have so many limitations and emergence of drug resistant strains...
FORMULATION AND EVALUATION OF MATRIX TYPE TRANSDERMAL PATCHES OF GLIBENCLAMIDE
Matrix type transdermal patches containing Glibenclamide were prepared using three different polymers by solvent evaporation technique. Aluminium foil cup method was used as a substrate. Polyethylene glycol (PEG) 400 was...
EVALUATION OF ANTI-DIABETIC ACTIVITY OF BAMBUSA VULGARIS LEAVES IN STREPTOZOTOCIN INDUCED DIABETIC RATS
The leaves of Bambusa vulgaris possesses several bioactivities and is used in traditional medicinal systems. However, its anti-diabetic activity has not been scientifically investigated so far. The present study was carr...