IN SILICO STUDIES ON DENGUE AND ZIKA VIRAL PROTEINS WITH SELECTED EMBLICA OFFICINALIS GAERTN CONSTITUENTS
Journal Title: World Journal of Pharmaceutical and life sciences - Year 2018, Vol 4, Issue 12
Abstract
Medicinal plants are the precious gift of nature which plays vital role in health care sector for developing nation and potent source of therapeutic molecules to heal various diseases in the world. Emblica officinalis Gaertn (Amla) is widely used in the Indian system of medicine and believed to increase defense against diseases and is also known for its therapeutic properties. Phytochemicals present in Emblica officinalis Gaertn are found to have antiinflammatory, antibacterial and antioxidant properties. This article describes the study of the binding efficiency of the selected 4 compounds that are present in the Emblica officinalis with seven proteins from Dengue virus and six proteins from Zika virus through in silico methods. By our virtual screening and docking result, we found that the Benzoic acid,3,4,5-trihydoxy- Compound has highest binding affinity with the proteins of Dengue and Zika virus.
Authors and Affiliations
Balasubramanian Sathyamurthy
Keywords
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