In Vitro α-Amylase Inhibitory Activity and GC- MS Analysis of Petrea volubilis
Journal Title: International Journal of Science and Research (IJSR) - Year 2015, Vol 4, Issue 4
Abstract
One of the therapeutic approaches which involve decreasing hyperglycemia aims at inhibiting the enzyme α-amylase. The aim of the present study was to investigate the in vitro anti-diabetic activity of the methanolic extract of Petrea volubilis. The assay results showed that the extract exhibit the dose-dependent increase in inhibitory effect on alpha-amylase enzyme upto 81.57% with IC 50 value 24.75±0.294 µg/ml. GC- MS analysis of root sample suggests that 1,2-Benzenedicarboxylic acid, mono(2- ethylhexyl) ester compound may be responsible to decrease hyperglycemia. This study shows that the roots of Petrea volubilis were most effective in inhibiting α-amylase, thereby proving to be potential anti-diabetic agents.
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