Abstract

Abstract Syzygium alternifolium walp. (Myrtaceae) has been traditionally used for the treatment of various ailments such as stomach ache, ulcers, rheumatism and diabetes. Preliminary phytochemical screening revealed the presence of phenols and flavonoids. Thus the total phenolic, flavonoids contents, in vivo and in vitro antioxidant potential were evaluated from the ethanolic extract of Syzygium alternifolium leaves. The antioxidant activity was determined by in vivo methods such as LPO, GSH and catalase levels and in vitro methods such as DPPH scavenging assay, Nitric oxide assay. The extract exhibited potential antioxidant activity in both in vivo and in vitro studies, associated with the total phenolic and flavonoid contents. The percentage inhibition of the extract followed dose-dependency and found significant (P < 0.001) as compared to standard (ascorbic acid) for DPPH and NO. The extract showed a significant (P < 0.001) increase in GSH levels and serum catalase activity and decrease in LPO levels when compared with the control group. Hence Syzygium alternifolium can be considered as a potent antioxidant in comparision with satandard Ranitidine in a dose dependent manner.

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