IN VITRO AND IN VIVO STUDY OF ANTI-DERMATOPHYTIC ACTIVITY OF THYMOL, CARVACROL, EUGENOL AND MENTHOL
Journal Title: World Journal of Advance Healthcare Research - Year 2018, Vol 2, Issue 5
Abstract
The aim of this work is to test the anti-dermatophytic activity of some Major Compounds (MCs) of Essential oils (EOs) (eugenol, menthol, thymol and carvacrol) against three dermatophytes isolated from clinical cases of dermatophytosis (Trichophyton violaceum, Microsporum canis and Trichophyton mentagrophyte). The anti-dermatophytic activity of MCs was tested in vitro by using: the broth dilution method and the agar dilution method in order to determine the minimal inhibitory concentration (MIC) and the minimal fungicidal concentration (MFC). The activity was then tested in vivo by using an experimental model of induced dermatophytosis in rabbits. Carvacrol and thymol revealed an anti-dermatophytic effect against all tested with (MIC) and (MFC) values between 250 μg/ml and 1000 μg/ml. The sporulation of target dermatophyte species decreased with increasing concentrations of MCs. As the most effective MC, thymol has shown a great effect on the treatment of skin dermatophytosis in rabbits caused by T. violaceum and M.canis. A significant reduction of the number of colonies sampled from the infected skin was observed at 1000 μg/ml compared to untreated control rabbits. These results demonstrated that thymol and carvacrol are potential sources of natural fungicides and could be used as an alternative to chemical anti-dermatophytic drugs.
Authors and Affiliations
Dr. Adnane Remmal
Keywords
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