IN VITRO ANTI DERMATOPHYTE ACTIVITIES OF CRUDE METHANOL AND AQUEOUS EXTRACTS OF LAWSONIA INERMIS
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2015, Vol 7, Issue 1
Abstract
The present study was carried out to investigate the in vitro anti dermatophyte activities of crude methanol and aqueous extracts of Lawsonia inermis leaves. The anti dermatophyte activities was tested against Microsporum audouinii, Microsporum ferrugineum, Trichophyton megninii, Trichophyton tonsurans and Trichophyton rubrum, recovered from rice farmers with fungal skin infections in Anambra State, Nigeria. From the result obtained, growth of dermatophytes was inhibited at the varied concentrations of crude methanol extract with the diameter zone of inhibition increasing with the increase in concentration. At the lowest concentration of 10 mg/disc, diameter zone of inhibition range of 8.0 mm-16.8 mm was recorded against the different dermatophytes. At 80 mg/disc, T. rubrum showed the highest diameter zone of inhibition (18.8 mm), followed by M. audouinii (18.0 mm) while T. megninii was the least inhibited (12.0 mm). Water extract of L. inermis also inhibited all the test dermatophyte. M. audouinii was the most susceptible with diameter inhibition zone of 14.5 mm. Minimum inhibitory concentration was recorded at 25 mg/ml for all dermatophytes while fungicidal action was recorded at concentrations of 50 mg/ml for M. audouinii and T. rubrum, 100 mg/ml for M. ferrugineum and 200 mg/ml for T. megninii and T. tonsurans. These results demonstrated that L. inermis has anti dermatophyte activities and could be a good source for the production of plant based antifungal drugs.
Authors and Affiliations
C. C. Ekwealor, C. A. Oyeka
Keywords
Related Articles
- EP ID EP625041
- DOI -
- Views 58
- Downloads 0
COMPARATIVE BIOAVAILABILITY STUDY WITH TWO SODIUM VALPROATE TABLET FORMULATIONS IN HEALTHY SUBJECTS
The aim was to assess the comparative bioavailability of two formulations (200 mg tablet) of sodium valproate in healthy subjects. This open label randomized, two periods, two treatments, two sequence, 2-way crossover de...
OPTIMIZATION OF CILNIDIPINE NANOSUSPENSION USING A CENTER COMPOSITE DESIGN
The purpose of this investigation was to increase the solubility and dissolution rate of Cilnidipine by the preparation of nanosuspensions with solvent antisolvent method at the laboratory scale. Drug solution of Cilnidi...
DESIGN AND SYNTHESIS OF 7-CHLORO-3-SUBSTITUTED QUINAZOLIN-4(3H)-ONES AS POTENTIAL ANTI-INFLAMMATORY AND ANALGESIC AGENTS
In our effort to identify potent anti-inflammatory and analgesic agents a number of 7-chloro-3-substituted-2-phenylquinazolin-4(3H)-ones have been synthesized starting from 4-chloro anthranilic acid. Docking analysis of...
DESIGN AND EVALUATION OF MICROSPHERES LOADED WITH PIRENZEPINE
The current objective of the investigation was to fabricate Pirenzepine loaded microspheres for the treatment of gastritis delivered through oral route. The microspheres were prepared by ionotropic gelation technique usi...
SELECTIVE CYTOTOXIC ACTIVITY OF SYNTHETIC NATURAL CYCLOPEPTIDES ON HCT11 & B16F10 CELLS
Peptides are natural messenger molecules of human body and hence ideal lead compounds for the initiation of drug discovery research. They are the important organic compounds with potent biological activities. Peptides fu...