In vitro Antibacterial Activity of Rhizome of Curcuma longa Linn. Against Pathogenic bacteria
Journal Title: International Journal of Ayurveda and Pharmaceutical Chemistry - Year 2018, Vol 0, Issue 0
Abstract
The aqueous, ethanol and petroleum ether extracts of the rhizomes of Curcuma longa Linn. (Family: Zingiberaceae) were screened for antimicrobial activity against five human pathogenic bacterial strains (gram positive bacteria i.e. Streptococcus pyogenes, Staphylococcus aureus, β-Haemolytic streptococcus and gram negative bacteria i.e. Pseudomonas aeuriginosa, Klebsiella pneumonia) responsible for skin and respiratory tracts infections commonly found in local community. Aim-The aim of the present study was to evaluate the antimicrobial activity of various solvent extracts of Curcuma longa Linn.(Family: Zingiberaceae). Methods-In vitro antimicrobial study of formulations was carried out by using the Agar well diffusion method for the assessment of anti- microbial activity. Three samples i.e. aqueous, alcoholic and petroleum ether extracts of the test drug (10 mg/ml each) along with Ciprofloxacin (5μg/ml) used as standard antibacterial drug were taken. Results and discussion-Ethanol extract showed significant sensitivity againstStreptococcus pyogenes, Pseudomonas aeuriginosa, Staphylococcus aureus, Klebsiella pneumonia and Betahaemolytic streptococcus with activity index as 0.66, 0.75, 0.6, 0.54 and 0.68respectively whereas Petroleum ether extract showed significant sensitivityagainst Klebsiellapneumonia with activity index0.72. Conclusion-Alcoholic extract was found effectiveagainst all five strains whereas aqueous extract was found effective against Klebsiella pneumoniabut definite validation requires further studies in animal models and in clinical studies on Respiratory tractand skin infections caused by these bacteria.
Authors and Affiliations
Debbarma Promod, Manjula . , Jaiswal Mohanlal
Keywords
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