In Vitro Antibacterial Activity, Phytochemical Analysis and Inhibitory Concentration of Bryophytes against Drug Resistant Bacterial Pathogens
Journal Title: International Journal of Advanced Biotechnology and Research. - Year 2016, Vol 7, Issue 2
Abstract
ABSTRACT: Natural plants especially high altitude plants provide unlimited opportunities for new drug leads because of the unmatched availability of chemical diversity. There is a continuous and urgent need to discover new antimicrobial compounds from the bryophytes from high altitude areas against new and re-emerging infectious diseases. In this study, the epiphytic bryophytes Homaliodendron montagneanum, Papillaria fuscescens and Campylopus latinervis were collected separately and was extracted by percolation method using various solvents like acetone, ethyl acetate and distilled water. The antimicrobial activity was evaluated against the different pathogenic bacterial strains using agar well diffusion method. The bryophyte extracts showed remarkable inhibitory activity against drug resistant bacterial pathogens. The extracts were further screened for phytochemical studies and they revealed the presence of alkaloids, flavonoids, phenol, proteins and amino acids, resins, saponins, steroids, tannins, xanthoproteins and sugars. The antimicrobial activities of bryophytes were due to the presence of various secondary metabolites, which may enhance at the high altitudes.. The Minimal Inhibitory Concentration of the acetone extract of H. montagneanum against Staphylococcus aureus MTCC 3160 is 20mg/ml and Minimal Bactericidal Concentration is 40mg/ml.
Authors and Affiliations
Prasanth G. Williams1, M. Reginald Appavoo1, Brijithlal N. D. 2, Reshma Surendran2 and *G. Prakash Williams 2
Keywords
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