In vitro antifungal susceptibility of Candida species isolated from oropharyngeal lesions of patients with cancer to some antifungal agents
Journal Title: Jundishapur Journal of Microbiology - Year 2011, Vol 4, Issue 1
Abstract
Introduction and objective: Oropharyngeal candidiasis is a relatively common mycotic infection in cancer patients. In vitro susceptibility of oropharyngeal Candida isolates can be useful in selecting the appropriate treatment for the best therapeutic outcome. The aim of this study was to evaluate the in vitro antifungal activity of Candida species against antifungal agents. Material and methods: In vitro activities of four antifungals were detected in 69 Candida isolates recovered from cancer patients in four university hospitals using the microdilution method described in the CLSI M27-A3 guideline. Result: Only 12(17.4%) of Candida isolate were resistant to antifungal agents. Three isolates (4.4% included C. albicans, C. glabrata, C. tropicalis, and C. pelliculosa) were resistant to amphotericin B, 5(7.2% included two C. albicans, two C. glabrata, and one C. kefyr) were itraconazole resistant. Two (2.9% include one C. albicans and one C. glabrata) were fluconazole resistant. Caspofungin resistance was detected in two C. infanticola strains which were reported as a clinical isolate for the first time. All Candida isolates (n=69) taken together gave minimum inhibitory concentration (MIC90) value for amphotericin B, fluconazole, itraconazole and caspofungin of 1, 0.25, 32 and 0.25μg/ml, respectively. In total, 18.7% of C. glabrata and 7.8% of C. albicans isolates were fully resistant to both itraconazole and fluconazole. Conclusion: Caspofungin had activity against oropharyngeal non- albicans Candida species isolates, particularly against those with reduced susceptibility to amphotericin B, fluconazole and itraconazole.
Authors and Affiliations
Tahereh Shokohi, Zainab Bandalizadeh, Mohmmad Taghi Hedayati, Sabah Mayahi
Keywords
Related Articles
- EP ID EP144960
- DOI -
- Views 116
- Downloads 0
Phospholipase activity of Candida albicans isolated from vagina and urine samples
Introduction and objective: Candida albicans is the most virulent among the Candida species, and can cause several forms of candidiasis in human. Extracellular phospholipases in C. albicans is discussed as one of the vir...
Analysis of genomic fingerprint patterns of coagulase-negative Staphylococci strains isolated from pediatric patients blood cultures using repetitive sequence-based PCR
Introduction and objective: Coagulase negative Staphylococci (CoNS) are often isolated from blood cultures which may represent either contamination or bacteremia. Repetitive sequence-based PCR (rep-PCR) as a suitable and...
In vitro antifungal susceptibility of Candida species isolated from oropharyngeal lesions of patients with cancer to some antifungal agents
Introduction and objective: Oropharyngeal candidiasis is a relatively common mycotic infection in cancer patients. In vitro susceptibility of oropharyngeal Candida isolates can be useful in selecting the appropriate trea...
Molecular epidemiology of Echinococcus granulosus strains in domestic herbivores of Lorestan, Iran
Introduction and objective: Hydatidosis is one of the most important common zoonosis diseases in most parts of the world. This parasite causes many damages to animal husbandry. Several strains of this parasite have been...
In vitro activity of six antifungal drugs against clinically important dermatophytes
Introduction and objective: Dermatophytosis is a common fungal disease which involves the keratinized tissue. Several antifungal agents can be used to manage these infections. Unfortunately, drug resistant can result in...