In Vitro Antimicrobial and Antioxidant Activity of Biogenically Synthesized Palladium and Platinum Nanoparticles Using Botryococcus braunii
Journal Title: Turkish Journal of Pharmaceutical Sciences - Year 2020, Vol 17, Issue 3
Abstract
Objectives: The spread of infectious diseases and the increase in drug resistance among microbes has forced researchers to synthesize biologically active nanoparticles. Ecofriendly procedures for the synthesis of nanoparticles are improving day by day in the field of nanobiotechnology. In the present study we used extract of the green alga Botryococcus braunii for the synthesis of palladium and platinum nanoparticles and evaluated their antimicrobial and antioxidant activity. Materials and Methods: Green alga was collected from Udaisagar Lake, Udaipur (Rajasthan, India) and isolated by serial dilution method and grown on Chu-13 nutrient medium. The characterization of alga synthesized palladium and platinum nanoparticles was carried out using X-ray diffraction and scanning electron spectroscopy. The zone of inhibition was measured by agar well plate method and minimum inhibitory concentration was determined by agar dilution assay for antimicrobial activity. The antioxidant activity of the nanoparticles was also studied by 1,1-diphenyl-2-picrylhydrazyl method. Results: Stable palladium and platinum nanoparticles were successfully produced using green alga. The XRD pattern revealed the crystalline nature and scanning electron micrographs showed the morphology of biogenically synthesized metal nanoparticles. Fourier transform infrared measurements showed all functional groups having control over stabilization and reduction of the nanoparticles. The green synthesized nanoparticles exhibited antimicrobial activity against gram-positive and gram-negative bacterial strains, antifungal activity against a fungus, and antioxidant activity. Conclusion: The biogenic synthesis of metal nanoparticles can be a promising process for the production of other transition metal nanoparticles and new nanocatalysts will revolutionize the synthesis of organic heterocycles.
Authors and Affiliations
Anju ARYA, Khushbu GUPTA, Tejpal Singh CHUNDAWAT
Keywords
Related Articles
- EP ID EP684764
- DOI 10.4274/tjps.galenos.2019.94103
- Views 157
- Downloads 0
In Vitro Macrophage Nitric Oxide and Interleukin-1 Beta Suppression by Moringa peregrina Seed
Objectives: Moringa peregrina has long been used in folk medicine to treat diseases including fever, headache, burns, constipation, gut pains, and inflammation. Nitric oxide (NO) and interleukin-1β (IL-1β) play an import...
Evaluation of Lactose-Based Direct Tableting Agents’ Compressibility Behavior Using a Compaction Simulator
Objectives: A compaction simulator (CS) is a single-punch instrument that records data during the powder compaction process. The aim of the study was to determine the behavior of lactose-based direct tableting agents (DT...
Global DNA Hypomethylation and Rassf1a and c-myc Promoter Hypermethylation in Rat Kidney Cells after Bisphenol A Exposure
Objectives: Bisphenol A (BPA) is a synthetic monomer used in the production of polycarbonate and an environmental contaminant with endocrine disrupting properties. BPA release from plastic carriers is thought to cause hi...
New Therapeutic Approaches in Cystic Fibrosis
Cystic fibrosis (CF) is a hereditary, multisystemic disease caused by different mutations in the CFTR gene encoding CF transmembrane conductance regulator. CF is mainly characterized by pulmonary dysfunction as a result...
Sun Protective Potential and Physical Stability of Herbal Sunscreen Developed from Afghan Medicinal Plants
Objectives: The aim of this study was to develop an herbal topical sunscreen formulation based on some fixed oils in combination with some medicinal plants. Materials and Methods: The crude and purified extracts were sc...