IN VITRO ANTIOXIDANT ACTIVITY ASSESSMENT ON ALCOHOLIC EXTRACT OF CYANOBACTERIA CULTURES FROM SPIRULINA PLATENSIS
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2013, Vol 2, Issue 3
Abstract
The antioxidant supplementation such as vitamin C, E, A and beta carotene etc, has proven to prevent the process of ageing caused by free radicals. Antioxidants either prevent free radical production or counteract the impeding damage by doing so they are involved in the protection and prevention of cellular damage which is the common pathway for cancer, aging and much disease. The cyanobacteria is a blue green micro algae believed to be a rich antioxidant source, found in abundance in Spirulina platensis is evaluated for antioxidant potential by modern in vitro techniques. METHODS the alcoholic extract of cyanobacteria is studied by in vitro Lipid Peroxidation inhibition assay (LPO) , The nitric oxide (NO)free radical scavenging activity and the determination of the DPPH (one, 1-diphenyl-2- picrylhydrazil) radical scavenging activity in concentrations which ranged from 1.95 g/mg to 500 g/mg in a geometric progression using spectrophotometer Results: The IC-50 % inhibition value of cyanobacteria by LPO is 102.70 mcg/ml, DPPH is 63.35 mcg/ml and by NO is 8.80 mcg/ml CONCLUSION The alcoholic extract of corynebacterium culture from Spirulina platensis exhibited potent NO free radical scavenging activity with mild activity on DPPH and LPO inhibition assay.
Authors and Affiliations
Senthilkumaran Jagadeesh J| Deparetment of Pharmacology, Sree Balaji Medical College and Hospital, Tamil Nadu, India, Corresponding author email:jagadeesh.j@gmail.com, Jaiganesh K| Department of Physiology, Mahatma Gandhi Medical College and Research Institute Pillaiyarkuppam, Pondicherry, India, Somasundaram G| Department of Pharmacology, Mahatma Gandhi Medical College and Research Institute Pillaiyarkuppam, Pondicherry, India
Keywords
Related Articles
- EP ID EP11027
- DOI 10.5958/j.2319-5886.2.3.108
- Views 312
- Downloads 22
PATTERN OF FRACTURES AND DISLOCATIONS IN A TERTIARY CARE HOSPITAL, NORTH EAST KARNATAKA
Background: Trauma including accidents are today’s world concern forming a major non-communicable epidemic accounting for mortality and morbidity. The aim of the study was to determine and account the types of fractu...
PREDICTION OF WEIGHT OF CHILDREN AGED UP TO TWO YEARS BASED ON FOOT LENGHT IN ETHIOPE EAST LOCAL GOVERNMENT AREA OF DELTA STATE OF SOUTHSOUTH NIGERIA
Introduction: When a child is in a critical condition, it may not be hundred percent possible to determine the body weight using weighing scale. Under such a condition, paediatricians estimate weight using the age of t...
ACUTE AORTIC DISSECTION IN A YOUNG HEALTHY ATHLETE WITH ANDROGENIC ANABOLIC STEROID USE: A CASE REPORT
Background: Acute aortic dissection can occur at the time of intense physical exertion in strength-trained athletes like weight lifters, bodybuilders, throwers, and wrestlers. Rapid rise in blood pressure and history of...
A cross sectional survey on knowledge, attitude and practices of health care professionals towards tobacco control in south India
Smoking tobacco is one of the leading and preventable cause of death worldwide. Apart from the responsibility of the Governments and the Non-governmental organizations, it is the duty of every health care professional t...
Study on prevalence of neoplastic lesions of the esophagus in patients referred to health centers of Ahvaz in the years 2001-2004
Introduction: Esophageal cancer is a common malignancy that is fatal to a large extent. The incidence of esophageal cancer is significantly variable worldwide and squamous cell carcinoma is the most common type. About...