In Vitro Antioxidant Studies of Whole Plant Ethanolic Extract of Blepharisrepens (Vahl) roth.
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2013, Vol 2, Issue 3
Abstract
Antioxidant potential of whole plant ethanolic extract of Blepharisrepens (vahl) Roth was studied using different in vitro models like 1,1-diphenyl-2-picryl hydrazyl, 2,2-azinobis-(3-ethylbenzothizoline-6-sulphonate), nitric oxide, superoxide, hydroxyl radical and lipid peroxidation. Both the ethanol and aqueous extracts of Blepharisrepens (vahl) roth at 500 μg/ml showed maximum scavenging activity (89.32% and 89.12%) in quenching 1,1-diphenyl-2-picryl hydrazyl radical. The ethanol extract showed better scavenging activity (69.78%) of 1,1-diphenyl-2-picryl hydrazyl radical followed by the scavenging of nitric oxide radical (73.25%) compared to aqueous extract. In contrast, hydroxyl and superoxide radicals were effectively scavenged by aqueous extract. Total antioxidant capacity of ethanol and aqueous extracts at 500 μg/ml concentration was found to be 56.21 and 62.78 mg ascorbic acid equivalents, respectively. However, both the extracts showed only moderate lipid peroxidation inhibition activity. They were also found to contain considerable total flavonoids and phenols suggesting their role as an effective free radical scavenger. These findings suggest that flavonoids in the whole plant Blepharisrepens (vahl) roth provide substantial antioxidant activity.
Authors and Affiliations
Rajan. M
Keywords
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