In vitro antioxident and free radical scavenging studies of Carissa Spinarum L
Journal Title: International Journal of Allied Medical Sciences and Clinical Research - Year 2016, Vol 4, Issue 1
Abstract
Free radicals are implicated for many diseases including cancer, diabetes mellitus, arthritis, ageing etc. In the treatment of these diseases, antioxidant therapy has gained very importance. Various extract of Carissa spinarum L was studied for its in vitro antioxidant activity used different models viz. ABTS radical scavenging, DPPH radical scavenging, H2O2, Hydroxyl radical, lipid peroxidation and Super oxide. The results were analyzed statistically by the regression methods. The scavenging effect of plant extracts and standard (L.ascorbic acid) on the various scavenging methods in the following order L-ascorbic acid >Ethanol>Ethyl acetate>Chloroform>Pet ether. Its antioxidant activity was estimated by IC50 value and the values are 102.6 to 244.2 μg/ml (ABTSradical scavenging), 200.41 to354.42 μg/ml (DPPH radical scavenging), 152.31to 236.12 μg/ml (H2O2), 188.74 to 296.41 μg/ml (Hydroxyl radical), 142.12 to291.41 μg/ml (Lipid peroxidation), and 157.42 to 306.16 μg/ml (Super oxide). The results clearly indicate that Carissa spinarum L has a significant potential to use as a natural antioxidant agent.
Authors and Affiliations
K . Sumathi
Keywords
Related Articles
- EP ID EP419756
- DOI -
- Views 51
- Downloads 0
A case report on management of dilated cardiomyopathy
Dilated cardiomyopathy is a progressive disease of heart muscle that is characterized by ventricular chamber enlargement and contractile dysfunction. The right ventricle may also be dilated and dysfunctional. Dilated car...
Comparision of Paraffin Wax Therapy Versus Low Level Laser Therapy in Patients with Trigger Point in Tennis Elbow-A Pilot Study
Background Lateral Epicondylitis also known as tennis elbow affects the wrist extensor muscles .Pain occurs due to repetitive microtrauma between 30 and 55 years. It affects 1%-3% of the population and mostly involves th...
To study the clinical and histopathological correlation of skin lesion - an original research article
Background Dermatological disorders are very common in all parts of the country but the spectrum may vary from region to region.[1] The skin diseases are more common in developing countries, which could benefit from publ...
Prevalence of foot drop in lumbar degenerative disease
The purpose of this study is to find out prevalence of foot drop in lumbar degenerative disease. 100 patients suffering from lumbar degenerative disease were included in the study between age group of 25-55 years from bo...
Evaluation of the facilitating skills of clinical instructors in the supervision of related learing experience (RLE) in selected colleges of nursing in quezon city, Manila, Philippines
A college have good facilities, money, well-designed program and leadership; however, a very large extent of successful delivery of services depends on the quality of persons engaged in the educational process and effect...