IN VITRO COMPARATIVE STUDIES ON SUSCEPTIBILITY PATTERNS OF PSEUDOMONAS AERUGINOSA AND STAPHYLOCOCCUS AUREUS TO CEFEPIME AND CEFPIROME
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 5
Abstract
The aim of this study was to gather the epidemiological data on the susceptibility patterns of Pseudomonas aeruginosa and staphylococcus aureus against fourth generation cephalosporins (Cefpirome and Cefepime). Total 100 isolates of each bacterial species were collected from central laboratories of different private hospitals of Karachi, Pakistan between September 2012 and December 2012. Modified Kirby-Bauer disc diffusion method was used for the determination of sensitivity of Cefpirome and Cefepime using strains of Pseudomonas aeruginosa (ATCC 27853) and staphylococcus aureus (ATCC 6538) as control. In-vitro comparative susceptibility patterns of Cefpirome and Cefepime were studied. Isolates of Pseudomonas aeruginosa were found to be resistant, 15% against Cefepime and 18% against Cefpirome while that of staphylococcus aureus were 3% against Cefepime and 5% against Cefpirome. Results clarify that Pseudomonas aeruginosa is more resistant as compare to staphylococcus aureus against both of the fourth generation cephalosporins. It is concluded from this study that Cefepime and Cefpirome are highly effective against Pseudomonas aeruginosa and Staphylococcus aureus and can be used safely in the treatment of infections caused by these organisms.
Authors and Affiliations
Humza , Ullah Ahmad , Khalid Khan , Sahrish Jamil , Ayaz Taj , Atif Anwer
Keywords
Related Articles
- EP ID EP135815
- DOI 10.7897/2230-8407.04528
- Views 106
- Downloads 0
THERAPEUTIC AND NUTRITIONAL SIGNIFICANCE OF DUGDHA (MILK) WITH REFERENCE TO COW’S MILK
Godugdha (Cow’s milk) is also elixir of life. Dugdha (milk) is a general term for the milk of any of the animals. In Ayurveda, Cow’s milk is much appreciated for the therapeutic purposes as well as nutrition, so that it...
FORMULATION DEVELOPMENT AND EVALUATION OF DIDANOSINE SUSTAINED- RELEASE MATRIX TABLETS USING HPMC K100
The present investigation concerned with formulation design and evaluation of oral sustained release matrix tablets of Didanosine (DDI) prepared by direct compression method using various proportion of release retarding...
SUSTAINED RELEASE DEVICE CONTAINING ORNIDAZOLE FOR PERIODONTITIS
The purpose of this study was to develop a sustained release device containing ornidazole for insertion within periodontal pockets. Cast films of ethyl cellulose with dibutyl phthalate as plasticizer, containing ornidazo...
SYNTHESIS AND ANTHELMINTIC ACTIVITY OF 2-AMINO-6-SUBSTITUTED BENZOTHIAZOLES
A series of 2-amino-substituted benzothiazoles (1-9) were synthesized by treating with KSCN in presence of bromine/glacial acetic acid with different substituted anilines. Structures of the all the synthesized compounds...
ROLE OF PHARMACIST TOWARDS KNOWLEDGE ATTITUDE AND PRACTICE IN COMPLIANCE WITH HYPERTENSION IN NORTH KARANATAKA IN SOUTH INDIAN CITY A BRIEF OVERVIEW
It is well known that the management of hypertension reduces the incidence further complications like myocardial infarction, stroke and vascular complications. Hypertension is a major health problem with individual, soci...