In vitro Dissolution Enhancement of Azithromycin in Solid Dispersion with PEG 6000 and β-CD
Journal Title: Journal of Pharmaceutical and Biomedical Sciences - Year 2016, Vol 6, Issue 10
Abstract
Azithromycin is a broad spectrum antimicrobial agent. It is poorly soluble in water. Therefore, the objective of this study was to increase the solubility and dissolution rate of Azithromycin Dihydrate (ATZ) by solid dispersion (SD) technique. The physical mixture (PM) and SD of ATZ was prepared by using various ratios of drug with PEG 6000 (PEG) and β–cyclodextrin (β-CD) by using the solvent evaporation method. The prepared PM and SD were evaluated for rheological properties, drug content and drug release. The drug release studied showed that the dissolution rate of SD was higher than those the PM of the drug. Drug–polymer interactions were investigated using FT-IR spectra which revealed no chemical incompatibility between drug and polymer.
Authors and Affiliations
Shailendra Wadhwa
Keywords
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