IN-VITRO EFFECTS OF CADMIUM, CHROMIUM, MANGANESE AND ZINC ON THE ANTIMICROBIAL ACTIVITY OF CHLORAMPHENICOL
Journal Title: Journal of Basic and Clinical Pharmacy - Year 2010, Vol 1, Issue 4
Abstract
Heavy metals have been shown to interact with various antibiotics resulting in differing spectrum of activity than that of the parent drug. In the present study the nature of antimicrobial activity exhibited by chloramphenicol in the presence of Cd,Cr, Mn and Zn at 37°C against S. typhii, S. aureus, E. coli, P. vulgaris and K. pneumoniae were evaluated. Broth dilution method of antimicrobial susceptibility testing was used to determine the minimum inhibitory concentration (MIC) of chloramphenicol against the organisms, while the cup-plate agar diffusion technique was used to quantify antimicrobial activity of the free drug and drug-metal mixtures. Results obtained for the interactions showed both decrease and increase in chloramphenicol activity depending on the type and concentration of the metal involved, and also on the organism.The resultant change in spectrum and profile of activity can result in unpredictable clinical efficacy of this drug and they should be avoided where possible.
Authors and Affiliations
Musa. A, Yakasai. A, Garba. M, Udekwe. C, Olayinka. O
Keywords
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