In vitro Effects of Persea americana Aqueous Extracts Against Oxidants and Fe2+Induced Oxidative Stress in Rats’ Pancreas
Journal Title: Tropical Journal of Natural Product Research - Year 2018, Vol 2, Issue 6
Abstract
Received 19 May 2018 Revised 05 June 2018 Accepted 07 June 2018 Published online 07 June 2018 Various mechanisms have been reported to orchestrate the antioxidant properties of bioactive compositions of medicinal plants in the management/treatment of many diseases. In this research, we focused on the antioxidant and anti-lipid peroxidation potential of aqueous extracts of Persea americana. Total phenol content, total flavonoid content, ferric reducing antioxidant property (FRAP), OH- radical scavenging ability, 1, 1-diphenylpicryhydrazyl (DPPH) radical scavenging ability and anti-lipid peroxidation strength of the extracts were estimated using 5 mg/mL. Leaf and seed extracts showed the highest total phenol and flavonoid contents respectively, while the FRAP of the seed was significantly (P < 0.05) higher than others. IC50 values revealed that Peel (IC50 = 0.335 ± 0.067) has the highest DPPH potential while OH- radicals and MDA were significantly (P < 0.05) reduced by the leaf extract in a dose dependent pattern. Characterization of avocado leaf and fruit parts revealed varied concentrations of phenolics (Syringic acid, eugenol, vnillic acid, isoeugenol, guaiacol, phenol, kaempherol, catechin, ρ-hydroxybenzoic acid, ferulic acid, apigenin, naringenin, epigallocatechin, lupeol and epigallocatechin-3-O-gallate). Our findings showed that the aqueous extract of the leaf and fruit parts of avocado pear (P. americana) protected the pancreas from Fe2+ induced lipid peroxidation in vitro which could be attributed to their phenolic compounds and this may be due to their antioxidant activities, Fe2+ chelating ability, radical scavenging strength and reducing power. This research therefore suggests the use of avocado pear as a functional food for the management of oxidative stress related diseases.
Authors and Affiliations
Temitope I. Adelusi, Ganiyu Oboh, Ayodele J. Akinyemi
Keywords
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- EP ID EP490866
- DOI 10.26538/tjnpr/v2i6.8
- Views 94
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